A decline in cognitive function following cancer treatment is one of the most commonly reported post-treatment symptoms among patients with cancer and those in remission, and include...
Read More »Modulating the Non-Hodgkin Lymphoma microenvironment with exosomes
There has been a shift in the paradigm of Non-Hodgkin lymphomas, changing from the classical genetic aberration-based model to a more complex and dynamic model involving tumor microenvironment interactions. In this instance, exosomes have...
Read More »Extracellular vesicles as conduits of non-coding RNA emission
Non-coding RNA (ncRNA) species have emerged in as molecular fingerprints and regulators of brain tumor pathogenesis and progression. While changes in ncRNA levels have been traditionally regarded as...
Read More »Proteomic insights into extracellular vesicle biology – defining exosomes and shed microvesicles.
Extracellular vesicles (EVs) are critical mediators of intercellular communication, capable of regulating the transcriptional landscape of target cells through horizontal transmission of biological information, such as proteins, lipids, and RNA species. This capability highlights their potential as novel targets for ...
Read More »Exosomal miRNAs as cancer biomarkers and therapeutic targets
Intercommunication between cancer cells and with their surrounding and distant environments is key to the survival, progression and metastasis of the tumour. Exosomes play a role in this communication process. MicroRNA (miRNA) expression is frequently dysregulated in tumour cells and ...
Read More »Intercellular communication via exosomes is essential in the maintenance and development of multicellular organisms
Intercellular communication is an essential bedrock in the maintenance and development of multicellular organisms. Conventional models of cellular exchange include transfer of secreted molecules and direct contact; only recently, exosomes have emerged as a new avenue for cell-to-cell communication. Discovered ...
Read More »Extracellular vesicles as carriers of microRNA, proteins and lipids in tumor microenvironment
In recent years the knowledge about the control of tumor microenvironment has increased and emerged as an important player in tumorigenesis. The role of normal stromal cells in the tumor initiation and progression has brought our vision in to the ...
Read More »Routes and mechanisms of extracellular vesicle uptake
Extracellular vesicles (EVs) are small vesicles released by donor cells that can be taken up by recipient cells. Despite their discovery decades ago, it has only recently become apparent that EVs play an important role in cell-to-cell communication. EVs can ...
Read More »miRNA cargo within exosome-like vesicle transfer influences metastatic bone colonization
Bone metastasis represents one of the most deleterious clinical consequences arising in the context of many solid tumors. Severe osteolysis results from tumor cell colonization of the bone compartment, a process which entails reciprocal exchange of soluble signals between tumor ...
Read More »Microvesicles and exosomes for intracardiac communication
The heart is an organ with a complex mixture of well-organized interactions of different cell types that facilitate proper myocardial contractility, sufficient perfusion, balanced myocardial extracellular stiffness, and controlled functioning of the immune system. Several cell types, including cardiomyocytes, endothelial ...
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