Bacterial Extracellular Vesicles (EVs) are bilayered lipid membrane structures, bearing integral proteins and able to carry diverse cargo outside the cell to distant sites. In microorganisms, EVs carry several...
Read More »An NGS based approach to identify exosomes mediated cell-to-cell communication
Exosomes and other extracellular vesicles (EVs) have emerged as an important mechanism of cell-to-cell communication. However, previous studies either did not fully resolve what genetic materials were shuttled by exosomes or only focused on a specific set of...
Read More »Exosomes – new molecular targets of diseases
Extracellular vesicles (EVs) comprise apoptotic bodies, microvesicles and exosomes, and they perform as key regulators in cell-to-cell communication in normal as well as diseased...
Read More »Exosomes as new players in metabolic organ cross-talk
Blood glucose homeostasis requires a constant communication between insulin-secreting and insulin-sensitive cells. A wide variety of circulating factors, including hormones, cytokines and chemokines work together to orchestrate the systemic response of metabolic organs to changes in the nutritional state. Failure ...
Read More »NIH awards $1.5 million to silence chatter among cancer cells
With the support of a new $1.58 million grant from the National Institutes of Health (NIH), University at Buffalo researchers aim to develop a targeted treatment to prevent communication between cancer cells. By developing biomaterials that target exosomes – lipid ...
Read More »Exosomes and Other Extracellular Vesicles in HPV Transmission and Carcinogenesis
Extracellular vesicles (EVs), including exosomes (Exos), microvesicles (MVs) and apoptotic bodies (ABs) are released in biofluids by virtually all living cells. Tumor-derived Exos and MVs are garnering increasing attention because of their ability to participate in cellular communication or transfer ...
Read More »Function of extracellular vesicle-associated miRNAs in metastasis
Extracellular RNA (exRNA) is functionally transferrable from donor to recipient cells and is protected from RNAses by electrostatic interactions with proteins or by membrane encapsulation. In addition to bioactive RNA, extracellular vesicles (EVs) contain intraluminal and membrane-associated proteins. The cellular ...
Read More »Exosomes in human atherosclerosis: An ultrastructural analysis study
Cell-to-cell communication, or signaling, is absolutely essential in orchestrating the activities of cells in multicellular organisms, to grow, develop, detect environmental changes and compensate for them in an internal, coordinated fashion. In the last few years, a considerable amount of ...
Read More »Lung cancer breakthrough in drug delivery
A breakthrough in research at UNC has created a method that both kills drug-resistant lung cancer and uses 50 times less chemotherapy. Elena Batrakova, senior author of the study, and her colleagues from the Eshelman School of Pharmacy’s Center for ...
Read More »New way to repair nerves – Using exosomes to hijack cell-to-cell communication
Research by Assistant Professor of Biomedical Engineering Qiaobing Xu and colleagues could lead to new ways to repair nerve tissue injuries. MEDFORD/SOMERVILLE, Mass. (Sept. 15, 2015) — Regenerative medicine using stem cells is an increasingly promising approach to treat many ...
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