Tag Archives: Chemotherapy

A decline in cognitive function following cancer treatment is one of the most commonly reported post-treatment symptoms among patients with cancer and those in remission, and include...

Endothelial cells (blue/grey) internalizing exosomes (red) released from chemotherapy-treated tumors Some patients with breast cancer receive chemotherapy before the tumor is removed with surgery. This approach, called ‘neoadjuvant’...

Cancer-associated fibroblasts (CAFs) comprise the majority of the tumor bulk of pancreatic ductal adenocarcinomas (PDACs). Current efforts to eradicate these tumors focus predominantly on targeting the proliferation of rapidly growing cancer epithelial cells. We know that this is largely ineffective ...

Exosomes, nanovesicles released from most cell types to extracellular compartments, are abundant in systemic circulation [1]. Exosome release is induced by stress conditions including oxidative stress [2,3]. Nearly 50% of FDA-approved chemotherapeutic drugs cause oxidative stress leading to long-term side ...

A breakthrough in research at UNC has created a method that both kills drug-resistant lung cancer and uses 50 times less chemotherapy. Elena Batrakova, senior author of the study, and her colleagues from the Eshelman School of Pharmacy’s Center for ...

Cancer drugs packaged in immune bubbles home in directly to tumors without getting sidetracked and destroyed; less chemo with better results Chapel Hill, N.C. – (Jan.14, 2016) —The cancer drug paclitaxel just got more effective. For the first time, researchers ...

St Charles Gairdner Hospital medical oncologist Annette Lim with a sequencing chip used in cancer research. PASSIONATE cancer researcher Annette Lim thinks her team could eventually save patients from unnecessary chemotherapy and radiotherapy. The medical oncologist from Sir Charles Gairdner ...

How exosomic microRNAs (miRNAs) contribute to the development of drug resistance in the context of the tumor microenvironment has not been previously described in neuroblastoma (NBL). Coculture experiments were performed to assess exosomic transfer of miR-21 from NBL cells to ...

Exosomes denote a class of secreted nanoparticles defined by size, surface protein and lipid composition, and the ability to carry RNA and proteins. They are important mediators of intercellular communication and regulators of the cellular niche, and their altered characteristics ...