Exosomes, nanovesicles released from most cell types to extracellular compartments, are abundant in systemic circulation [1]. Exosome release is induced by stress conditions including oxidative stress [2,3]. Nearly 50% of FDA-approved chemotherapeutic drugs cause oxidative stress leading to long-term side ...
Read More »The battlefield of biomarker discovery is littered with fallen candidates
In clinical oncology, detecting and treating disease as early as possible is the brass ring to be grasped. Does a new test based on circulating exosomes bring it closer for patients with pancreas cancer? Most solid tumors are incurable once ...
Read More »Automated rapid and reproducible exosome extraction from clinical samples
Exosome-mediated signal transportation plays a variety of critical roles in cancer progression and metastasis. From the aspect of cancer diagnosis, circulating exosomes are ideal resources of biomarkers because molecular features of tumor cells are transcribed on them. However, isolating pure ...
Read More »Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology
Developing blood-based tests is appealing for non-invasive disease diagnosis, especially when biopsy is difficult, costly, and sometimes not even an option. Tumor-derived exosomes have attracted increasing interest in non-invasive cancer diagnosis and monitoring of treatment response. However, the biology and ...
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