MicroRNAs (miRNAs) released into the peripheral circulation upon cellular injury have shown a promise as a new class of tissue-specific biomarkers. Researchers at Maastricht University were first to demonstrate that next-generation sequencing analysis of serum from human subjects with acetaminophen-induced ...
Read More »The Impact of Extracellular Vesicle-Encapsulated Circulating MicroRNAs in Lung Cancer Research
Lung cancer is the leading cause of cancer-related deaths. Biomarkers for lung cancer have raised great expectations in their clinical applications for early diagnosis, survival, and therapeutic responses. MicroRNAs (miRNAs), a family of short endogenous noncoding RNAs, play critical roles ...
Read More »Exosomal miRNAs as potential biomarkers of cardiovascular risk in children
Intercellular interactions are essential for basic cellular activities and errors in either receiving or transferring these signals have shown to cause pathological conditions. These signals are not only regulated by membrane surface molecules but also by soluble secreted proteins, thereby ...
Read More »Circulating microRNAs as biomarkers for evaluating the severity of acute spinal cord injury
Study design: An in vivo study in mouse models of spinal cord contusion. Objectives: To develop a novel indicator to anticipate the severity of spinal cord injury (SCI) during the acute phase and for the assessment of the efficacy of ...
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