Tag Archives: clinical

The important challenge about cancer is diagnosis in primary stages and proper treatment. Although classical clinico-pathological features of the tumor have major prognostic value, the advances in diagnosis and treatment are indebted to discovery of molecular biomarkers and control of ...

from Genetic Engineering News by Jeffrey S. Buguliskis, Ph.D. The term “biopsy” frequently evokes fear in patients, as the procedure is most often associated with cancer screening. Nevertheless, patient fears about biopsies are not wholly unwarranted and not simply due ...

Due to unsatisfying prognosis of AFP for hepatocellular carcinoma (HCC), researchers from the Chengdu Military General Hospital set out to evaluate the prognostic value of combination of exosomes and miRNAs in detecting HCC. HCC was induced with diethylnitrosamine in rats ...

Urinary exosomes are small (<100 nm) vesicles secreted into urine from renal epithelial cells. They are coated with lipid bilayer, they contain an array of membrane and cytosolic proteins, and selected RNA species, reflecting the molecular composition of their cell ...

Extracellular vesicles (EVs) are commonly used by normal and tumor cells for communication at long distances to exchange by complex molecular messages and deliver a variety of essential biomolecules. EVs (exosomes and microvesicles) released in large numbers by glioma cells ...

MicroRNAs (miRNAs) are small noncoding RNAs of 22 to 25 nucleotides in length that act through an RNA-induced silencing complex to posttranscriptionally regulate mRNAs that contain complementary sequences. Highly stable circulating miRNAs are found in biological fluids and are potential ...