Tag Archives: colorectal cancer

Liquid biopsy has become a useful alternative in metastatic colorectal cancer (mCRC) patients when tissue biopsy of metastatic sites is not feasible. In this study researchers at the Catholic University of Sacred Heart aimed to investigate the clinical utility of ...

The molecular profile of liquid biopsies is emerging as an alternative to tissue biopsies in the clinical management of malignant diseases. In colorectal cancer, significant liquid biopsy-based biomarkers have demonstrated an ability to discriminate between...

The regulation and functional roles of secreted coding and long noncoding RNAs (lncRNAs; >200 nt) are largely unknown. Researchers from the Vanderbilt University Medical Center previously showed that...

Accumulating data have suggested exosome-delivered microRNAs (miRNAs) play critical role in carcinogenesis and cancer progression. However, little is known about the influence of exosomal miR-6803-5p on the development and prognosis of colorectal cancer (CRC). Levels of serum exosomal miR-6803-5p were ...

Therapies based on RNA, such as small interfering RNA, hold great promise for cancer treatment but delivering these agents to their targets in cancer...

Exosomes are extracellular microvesicles released from cells, which are involved in many biological and pathological processes, mainly due to their role in intercellular communication. Exosomes derived from colorectal cancer (CRC) cells are related to oncogenesis, tumor cell survival, chemo-resistance and ...

Tumour cells of colorectal cancer (CRC) release exosomes into the circulation. These exosomes can mediate communication between cells and affect various tumour-related processes in their target cells. Researchers from the Chinese Academy of Medical Sciences present a quantitative proteomics analysis ...

Although there is a growing interest in developing circulating microRNA (miRNA) as noninvasive diagnostic biomarkers for the detection of high-risk colorectal adenomas and early-stage CRCs, but the comparative diagnostic significance of serum vs. exosomal miRNAs remains unexplored. Based upon published ...

Mikhail Fedyanin, MD, PhD, Russian Academy of Medical Science, discusses mutation discordance in the primary tumor and metastases in patients with colorectal cancer (CRC), as well as the benefits of liquid biopsy. A study found that patients with mutant RAS in the ...

from Oncology Times by Robert H Carlson – BARCELONA, Spain—Anti-EGFR monoclonal antibodies should only be considered for treatment of metastatic colorectal cancer patients whose tumors are wild type, but determining which patients are eligible by biopsy analysis is time consuming ...