tiakis Biotech announced the results of its randomized, double-blind, placebo-controlled clinical Phase Ib/II COMCOVID trial evaluating Tiprelestat for the treatment of patients hospitalized due to COVID.
Read More »Genomic communication via circulating extracellular vesicles and long-term health consequences of COVID-19
COVID-19 continues to affect an unprecedented number of people with the emergence of new variants posing a serious challenge to global health. There is an expansion of knowledge in...
Read More »Coagulation potential and the integrated omics of extracellular vesicles from COVID-19 positive patient plasma
Extracellular vesicles (EVs) participate in cell-to-cell communication and contribute toward homeostasis under physiological conditions. But EVs can also contribute toward a wide array of pathophysiology like...
Read More »Exploring extracellular vesicles as mediators of clinical disease and vehicles for viral therapeutics: Insights from the COVID-19 pandemic
The COVID-19 pandemic has challenged researchers to rapidly understand the capabilities of the SARS-CoV-2 virus and investigate potential therapeutics for...
Read More »Quantitative proteomics and biological activity of extracellular vesicles engineered to express SARS-CoV-2 spike protein
SARS-CoV-2 viral infection led to the devastating COVID-19 pandemic, where illness stemmed from interactions between virions and recipient host cells resulting in multi-layered pathological consequences...
Read More »ACE2-containing defensosomes serve as decoys to inhibit SARS-CoV-2 infection
Extracellular vesicles of endosomal origin, exosomes, mediate intercellular communication by transporting substrates with a variety of functions related to tissue homeostasis and disease. Their diagnostic and therapeutic potential has been recognized for...
Read More »Serum extracellular vesicles as powerful biomarkers for COVID-19 severity
COVID-19 is characterized by a wide spectrum of disease severity, whose indicators and underlying mechanisms need to be identified. The role of...
Read More »Inhalable COVID-19 vaccine of exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain
Researchers have created an inhalable COVID-19 vaccine that is shelf stable at room temperature for up to three months, targets the lungs specifically and effectively, and allows for self-administration via an inhaler. The researchers also found that the delivery mechanism ...
Read More »In long COVID, exosomal blood markers are linked to neuropsychiatric ills
In a new study of long COVID published March 13, 2022, in the Annals of Neurology, UC San Francisco researchers identified biomarkers present at...
Read More »Risk stratification of patients with SARS-CoV-2 by tissue factor expression in circulating extracellular vesicles
Inflammatory response following SARS-CoV-2 infection results in substantial increase of amounts of intravascular pro-coagulant extracellular vesicles (EVs) expressing tissue factor (CD142) on their...
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