Sensitive and specific detection of tumor exosomes is of great significance for early cancer diagnosis. Researchers from Nanjing Normal University report an aptamer strategy for exosome detection based on aptamer recognition-induced multi-DNA release and cyclic enzymatic amplification. First, they use aptamer-magnetic bead ...
Read More »New Patent Granted – Monoclonal antibody for detecting exosomes
The present invention relates to a set of antibodies for detecting an exosome. More particularly, the present invention relates to a monoclonal antibody against a particular antigen (CD9, CD63, CD81) on an exosomal surface or an antibody fragment thereof, a ...
Read More »Detection of exosomal prions in blood by immunochemistry techniques
In most forms of prion diseases blood is infectious, but the detection by immunochemistry techniques of the only available marker of infection (the misfolded prion protein, PrPTSE) in blood remains elusive. Researchers at the Istituto Superiore di Sanità, Italy developed ...
Read More »Detection of tumor cell-specific mRNA and protein in exosome-like microvesicles from blood and saliva
The discovery of disease-specific biomarkers in oral fluids has revealed a new dimension in molecular diagnostics. Recent studies have reported the mechanistic involvement of tumor cells derived mediators, such as exosomes, in the development of saliva-based mRNA biomarkers. To further ...
Read More »Analysis of extracellular RNA by digital PCR
The transfer of extracellular RNA is emerging as an important mechanism for inter-cellular communication. The ability for the transfer of functionally active RNA molecules from one cell to another within vesicles such as exosomes enables a cell to modulate cellular ...
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