Creative Medical Technology Holdings announced today filing a new patent application covering nanoparticles called “exosomes” secreted by cells of its...
Read More »Targeting exosome-associated human antigen R attenuates fibrosis and inflammation in diabetic heart
RNA-binding proteins like human antigen R (HuR) are key regulators in post-transcriptional control of gene expression in several pathophysiological conditions. Diabetes adversely affects monocyte/macrophage biology and function. It is not known whether diabetic milieu affects cellular/exosome-HuR and its...
Read More »Exosomes in heart disease and therapy
Exosomes are nanoscale membrane-bound extracellular vesicles secreted by most eukaryotic cells in the body that facilitates intercellular communication. Exosomes carry several signaling...
Read More »Using exosomal microRNA to detect early signs of type 2 diabetes in teens
Researchers know that exosomes, tiny nanoparticles released from fat cells, travel through the bloodstream and body, regulating a variety of processes, from growth and development to metabolism. The exosomes are important in lean, healthy...
Read More »Liquid biopsy microRNA biomarkers to predict risk for diabetic kidney disease
A recent study from the Madras Diabetes Research Foundation, Chennai, India & University of Lyon, France – brings a new hope for using ‘liquid-biopsy’ exosomal microRNA biomarkers (miRNAs) from urine to predict risk for kidney disease in diabetes patients...
Read More »Bioengineered extracellular vesicle-mimetic nanovesicles can serve as a powerful instrument to effectively deliver lncRNA
Diabetic wounds, one of the most enervating complications of diabetes mellitus, affect millions of people worldwide annually. Vascular insufficiency, caused by hyperglycemia, is one of the primary causes...
Read More »An NGS based approach to identify exosomes mediated cell-to-cell communication
Exosomes and other extracellular vesicles (EVs) have emerged as an important mechanism of cell-to-cell communication. However, previous studies either did not fully resolve what genetic materials were shuttled by exosomes or only focused on a specific set of...
Read More »A step closer to a cure for adult-onset diabetes – could “sick” exosomes be to blame
In healthy people, exosomes – tiny structures secreted by cells to allow intercellular communication – prevent clumping of the protein that leads to type 2 diabetes. Exosomes in patients with the disease don’t have the same ability. This discovery by ...
Read More »Exosomes as new players in metabolic organ cross-talk
Blood glucose homeostasis requires a constant communication between insulin-secreting and insulin-sensitive cells. A wide variety of circulating factors, including hormones, cytokines and chemokines work together to orchestrate the systemic response of metabolic organs to changes in the nutritional state. Failure ...
Read More »Exosomes are the Missing Link to Insulin Resistance in Diabetes
Chronic tissue inflammation resulting from obesity is an underlying cause of insulin resistance and type 2 diabetes. But the mechanism by which this occurs has remained cloaked, until now. In a paper, published in the journal Cell on September 21, ...
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