Tag Archives: diagnostic

Extracellular vesicles (EVs), or exosomes, are nanovesicles of endocytic origin that carry host and pathogen-derived protein, nucleic acid, and lipid cargos. They are secreted by most cell types and play important roles in normal cell-to-cell communications but can also spread ...

The fusion of plasma membrane with the internal vesicle fusion leads to the secretion of nanovescicles called exosomes into the extracellular environment. The exosomes are released in easily accessible body fluids such as urine and blood and hence acts as ...

New diagnostic technology platform developed by PlexBio is able to rapidly determine the status of a wide range of somatic gene mutations or gene rearrangements typically seen in various cancers. In combination with SelectAmp, a mutation-enriching PCR amplification technique that ...

Disclosed are methods of identifying tumor-derived exosomes as an early cancer diagnostic, as well as for staging, Publication number WO2016201064 A1 Publication type Application Application number PCT/US2016/036629 Publication date Dec 15, 2016 Filing date Jun 9, 2016 Priority date Jun ...

Despite enormous research strides, detection methods for many diseases remain cumbersome and expensive, and often uncover illness only at advanced stages, when patient outcomes can be bleak. One such illness is pancreatic cancer, which may display no obvious symptoms in ...

Exosome Diagnostics, Inc. has entered into an agreement with Amgen to evaluate the potential to advance drug development with Exosome’s proprietary liquid biopsy diagnostics technology and platform. Under the terms of the agreement, the companies will collaborate to identify a ...

Despite considerable research efforts, the finding of reliable tumor biomarkers remains challenging and unresolved. In recent years a novel diagnostic biomedical tool with high potential has been identified in extracellular nanovesicles or exosomes. They are released by the majority of ...

Myocardial infarction (MI) triggers a potent inflammatory response via the release of circulatory mediators, including extracellular vesicles (EVs) by damaged cardiac cells, necessary for myocardial healing. Timely repression of inflammatory response are critical to prevent and minimize cardiac tissue injuries, ...

Kalluri, Raghu (Houston, TX, US) Melo, Sónia (Porto, PT) Abstract The presently disclosed subject matter provides methods of diagnosis of cancer or adverse pregnancy outcomes in a subject by measuring amounts of one or more microRNAs present in cancer-derived exosomes ...

Alzheimer’s disease (AD) is the most common progressive degenerative disorder, and is characterized by memory loss and cognitive decline. It is a complex disorder with both environmental and genetic components. Current diagnosis of AD is based primarily on the analysis ...