All cells release a multitude of nanoscale extracellular vesicles (nEVs) into circulation, offering immense potential for new diagnostic strategies. Yet, clinical translation for nEVs remains a challenge due...
Read More »Proteomics method to identify protein profiles in exosomes
Exosomes are membrane-bound nanovesicles that transport molecular signals (e.g., proteins) between cells and are released from a wide range of cells, including the human placenta. Interestingly...
Read More »Recovery of serum exosomal microRNAs from FTA Elute cards for biomarker discovery and diagnostics
The preservation of nucleic acids from clinical samples is critical to facilitate accurate molecular diagnosis. The use of a paper matrix, Flinders Technology Associates (FTA) Elute cards, to archive DNA and viral RNA is well-documented. However, the feasibility of FTA ...
Read More »Isolating exosomes for cancer diagnostics
from Technology Networks by Anna MacDonald – Once considered cellular rubbish, exosomes are now known to play important roles in cellular communication. These small messengers are defined as “extracellular vesicles that are released from cells upon fusion of an intermediate ...
Read More »Insights of exosomes in neurodegenerative diseases
Exosomes are small membranous entities of endocytic origin. Their production by a wide variety of cells in eukaryotes implicates their roles in the execution of essential processes, especially cellular communication. Exosomes are secreted under both physiological and pathophysiological conditions, and ...
Read More »Researchers investigate the potential use of lipids in urinary exosomes as prostate cancer biomarkers
Exosomes have recently appeared as a novel source of noninvasive cancer biomarkers, since these nanovesicles contain molecules from cancer cells and can be detected in biofluids. Researchers from the Oslo University Hospital have investigated the potential use of lipids in ...
Read More »Exosomal proteins as prostate cancer biomarkers in urine
Exosomes have recently appeared as a novel source of non-invasive cancer biomarkers since tumor-specific molecules can be found in exosomes isolated from biological fluids. Researchers from Oslo University Hospital have previously analyzed the proteome of urinary exosomes by mass spectrometry, ...
Read More »Using liquid biopsies to detect cancer mutations
(SelectScience) – Dr Tobias Paprotka, Director Research and Development at GATC Biotech talked to SelectScience® about the company’s latest sequencing innovations for cancer diagnostics. GATC has developed optimized and automated protocols for its products in order to maximize quality and ...
Read More »Therapeutic and diagnostic applications of extracellular vesicles
During the past two decades, extracellular vesicles (EVs) have been identified as important mediators of intercellular communication, enabling the functional transfer of bioactive molecules from one cell to another. Consequently, it is becoming increasingly clear that these vesicles are involved ...
Read More »Exosome cancer diagnostic reaches market
The first blood-based cancer diagnostic to exploit free-floating exosomes became commercially available in the US on January 21. The launch of this ‘liquid biopsy’ from Exosome Diagnostics of Cambridge, Massachusetts, marks a step towards maturity for the fledgling science of ...
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