Exosome transfer of functional RNA to target cells is well described, whereas the mechanism of transfer of exRNA free of exosomes remains unclear. In the current study, a team led by researchers from Yale University School of Medicine describe extracellular ...
Read More »Antigen-specific exosomes act via antigen-presenting cells
There is a new study following up immune-suppression by antigen-specific exosomes coated with antibody light chains delivering inhibitory miRNA-150. It shows that the target is antigen-presenting macrophages, to then inhibit the function of antigen specific effector T cells. This follows ...
Read More »Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150
T-cell tolerance of allergic cutaneous contact sensitivity (CS) induced in mice by high doses of reactive hapten is mediated by suppressor cells that release antigen-specific suppressive nanovesicles. Researchers from the Jagiellonian University College of Medicine, Poland set out to determine ...
Read More »