Tag Archives: EGFR

Bio-Techne have researchers published a validation study demonstrating that the proprietary exosome-based liquid biopsy tests from Bio-Techne’s Exosome Diagnostics brand may be used to assess the...

Exomeres are a recently discovered type of extracellular nanoparticle with no known biological function. Researchers at Vanderbilt University Medical Center now describe a simple...

Molecular profiling has changed the treatment landscape in advanced non-small-cell lung cancer. Accurately identifying the tumours that harbour sensitizing EGFR mutations, the most common targetable molecular alteration, as well as those with acquired resistance mutations (e.g. T790M) on treatment is ...

A major limitation of circulating tumor DNA (ctDNA) for somatic mutation detection has been the low level of ctDNA found in a subset of cancer patients...

Lung Cancer Advisor – by Andrea S. Blevins Primeau – A liquid biopsy analysis shows inter- and intra-patient heterogeneity of EGFR resistance mutations among patients with lung adenocarcinoma who received EGFR-directed tyrosine kinase inhibitor (TKI) therapy, according to a study ...

from Oncology Times by Robert H Carlson – BARCELONA, Spain—Anti-EGFR monoclonal antibodies should only be considered for treatment of metastatic colorectal cancer patients whose tumors are wild type, but determining which patients are eligible by biopsy analysis is time consuming ...

Trovagene, Inc., a developer of circulating tumor DNA (ctDNA) molecular diagnostics, announced today that a patient case report featuring use of the Company’s Trovera™ EGFR urine-based liquid biopsy test was recently published in Experimental Hematology & Oncology.  Dr. David Berz, ...

Exosomes are small, 40-130 nm secreted extracellular vesicles that recently have become the subject of intense focus as agents of intercellular communication, disease biomarkers and potential vehicles for drug delivery. It is currently unknown whether a cell produces different populations ...

Exosomes are nanoscale membrane-derived vesicles that are secreted by cancer cells and play a critical role in modulating the tumor microenvironment and disease pathogenesis. Dsg2, a desmosomal cadherin often overexpressed in skin malignancies including squamous cell carcinoma (SCC), can activate ...

Extracellular vesicles (EVs) are attractive candidates for biomarker research, because their content reflects the parental cell status. Researchers from the University Medical Center Utrecht examined whether tumor cell derived EVs mirrored the cellular changes caused by treatment with cetuximab, a ...