Tag Archives: EGFR

Extracellular vesicles help cancer cells communicate with surrounding stromal cells, and targeted protein degradation may disrupt this signaling network to suppress tumor growth...

Targeted suppression of extracellular vesicles disrupted tumor-stroma communication, reprogrammed cancer-associated fibroblasts...

Extracellular vesicles released by EGFR-mutant lung cancer cells carry activated signaling proteins and are reduced by gefitinib, revealing a possible link...

Recent advances in cancer diagnostics have shown that messenger RNA (mRNA) found in extracellular vesicles (EVs) can provide critical insights into a...

Bio-Techne have researchers published a validation study demonstrating that the proprietary exosome-based liquid biopsy tests from Bio-Techne’s Exosome Diagnostics brand may be used to assess the...

Exomeres are a recently discovered type of extracellular nanoparticle with no known biological function. Researchers at Vanderbilt University Medical Center now describe a simple...

Molecular profiling has changed the treatment landscape in advanced non-small-cell lung cancer. Accurately identifying the tumours that harbour sensitizing EGFR mutations, the most common targetable molecular alteration, as well as those with acquired resistance mutations (e.g. T790M) on treatment is ...

A major limitation of circulating tumor DNA (ctDNA) for somatic mutation detection has been the low level of ctDNA found in a subset of cancer patients...

Lung Cancer Advisor – by Andrea S. Blevins Primeau – A liquid biopsy analysis shows inter- and intra-patient heterogeneity of EGFR resistance mutations among patients with lung adenocarcinoma who received EGFR-directed tyrosine kinase inhibitor (TKI) therapy, according to a study ...

from Oncology Times by Robert H Carlson – BARCELONA, Spain—Anti-EGFR monoclonal antibodies should only be considered for treatment of metastatic colorectal cancer patients whose tumors are wild type, but determining which patients are eligible by biopsy analysis is time consuming ...