EBV latent membrane protein 1 (LMP1) is released from latently infected tumor cells in small membrane-enclosed extracellular vesicles (EVs)...
Read More »Do exosomes play a pathogenic role in Epstein-Barr Virus (EBV)-associated cancers?
Exosomes are 40- to 100-nm membrane-bound small vesicles that carry a great variety of cellular cargoes including proteins, DNA, messenger RNAs (mRNAs), and microRNAs (miRNAs). These nanovesicles are detected in various biological fluids such as serum, urine, saliva, and seminal ...
Read More »Herpesviruses hijack host exosomes for viral pathogenesis
Herpesviruses are remarkable pathogens possessing elaborate mechanisms to seize various host cellular components for immune evasion, replication, and virion egress. As viruses are dependent upon their hosts, investigating this intricate interplay has revealed that the exosome pathway is utilized by ...
Read More »Intercellular communication via exosomes is essential in the maintenance and development of multicellular organisms
Intercellular communication is an essential bedrock in the maintenance and development of multicellular organisms. Conventional models of cellular exchange include transfer of secreted molecules and direct contact; only recently, exosomes have emerged as a new avenue for cell-to-cell communication. Discovered ...
Read More »Exosomal Communication Goes Viral
Exosomes are small vesicles secreted from cells that participate in intercellular communication events. Accumulating evidence demonstrates that host exosome pathways are hijacked by viruses and that viral-modified exosomes contribute to virus spread and immune evasion. In the case of tumor ...
Read More »Epstein-Barr Virus-Encoded Small RNAs (EBERs) Are Present Exosomes
Epstein-Barr virus (EBV) is an oncogenic herpesvirus associated with a number of human malignancies of epithelial and lymphoid origin. However, the mechanism of oncogenesis is unclear. A number of viral products, including EBV latent proteins and non-protein coding RNAs have ...
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