Sensitive and selective detection of microRNAs (miRNAs) in cancer cells derived exosomes have attracted rapidly growing interest owing to their potential in diagnostic and prognostic applications. Here, researchers from the Fujian Agriculture and Forestry University design a ratiometric electrochemical biosensor ...
Read More »Adipose-derived exosomal miRNAs regulate gene expression in other tissues
Adipose tissue is a major site of energy storage and has a role in the regulation of metabolism through the release of adipokines. Here researchers from the Joslin Diabetes Center and Harvard Medical School, show that mice with an adipose-tissue-specific ...
Read More »Next-generation sequencing-based small RNA profiling of cerebrospinal fluid exosomes
MicroRNAs (miRNAs), particularly those found in human body fluids, have been suggested as potential biomarkers. Among various body fluids, the cerebrospinal fluid (CSF) shows promise as a profiling target for diagnosis and monitoring of neurological diseases. However, relevant genome-scale studies ...
Read More »Identification of Endogenous Controls for Analyzing Serum Exosomal miRNA
Serum exosomal microRNAs (miRNAs) have received considerable attention as potential biomarkers for diagnosing cancer. The canonical technique for measuring miRNA transcript levels is reverse transcription quantitative polymerase chain reaction (RT-qPCR). One prerequisite for validating RT-qPCR data is proper normalization with ...
Read More »Systemically Circulating Viral and Tumor-Derived MicroRNAs
Circulating microRNAs (miRNAs), such as those found in exosomes, have emerged as diagnostic tools and hold promise as minimally invasive, stable biomarkers. Transfer of tumor-derived exosomal miRNAs to surrounding cells may be an important form of cellular communication. Kaposi’s sarcoma-associated ...
Read More »