Obesity is a global public health issue with serious health consequences and rising prevalence. It is a risk factor for a broad range of diseases, particularly atherosclerosis and cardiovascular disease. Long-term weight loss is difficult to achieve, even with diet, ...
Read More »Development of Antibody-Oligonucleotide Complexes for Targeting Exosomal MicroRNA
MicroRNAs in exosomes (exosomal miRNAs) are considered as significant targets for cancer therapy. Anti-miR oligonucleotides are often used for the functional inhibition of miRNAs; however, there are no studies regarding the regulation of exosomal...
Read More »A microfluidic device for detection and isolation of lung cancer-specific exosomes from urine
Exosomes, derived from various biofluids, may serve as potential biomarkers for cancer early detection. Nevertheless, exosome clinical translation remains...
Read More »Early-stage lung cancer diagnosis by deep learning-based spectroscopic analysis of circulating exosomes
Lung cancer has a high mortality rate, but an early diagnosis can contribute to a favorable prognosis. A liquid biopsy that captures and detects tumor-related biomarkers in body fluids has great potential for early-stage diagnosis. Exosomes, nanosized extracellular vesicles found ...
Read More »Clinical applications of exosome membrane proteins
Extracellular vesicles (EVs) are small membranous particles that can mediate cell-to-cell communication and which are divided into at least three categories according to their subcellular origin and size...
Read More »Tumor cell-derived exosomes can be used as Trojan horses to deliver cancer drugs
Cancer is the second leading cause of death worldwide and patients are in urgent need of therapies that can effectively target cancer with...
Read More »Rapid and sensitive exosome detection with CRISPR/Cas12a
Numerous studies have shown that exosomes are closely related to the pathogenesis of various diseases, especially cancers. Therefore, a rapid and sensitive method for exosome detection will be of...
Read More »An assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human CSF
Extracellular vesicle (EV) is a unified terminology of membrane-enclosed vesicular species ubiquitously secreted by almost every cell type and present in all body fluids. They carry a cargo of lipids, metabolites, nucleic acids and proteins for their clearance from cells ...
Read More »Inclusion biogenesis, methods of isolation and clinical application of human cellular exosomes
Exosomes are a heterogenous subpopulation of extracellular vesicles 30–150 nm in range and of endosome-derived origin. Despite more than 30 years of research that followed their definition and indicated their important role in cellular...
Read More »The Role of Exosomes in Metastasis and Progression of Melanoma
The mechanisms of melanoma metastasis have been the subject of extensive research for decades. Improved diagnostic and therapeutic strategies are...
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