Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) may deliver therapeutic effects that are comparable to their parental cells. MSC-EVs are promising agents for the treatment of a variety of diseases. To reach the intermediate...
Read More »Transfer of functional cargo in exomeres
Exomeres are a recently discovered type of extracellular nanoparticle with no known biological function. Researchers at Vanderbilt University Medical Center now describe a simple...
Read More »Reassessment of Exosome Composition
The heterogeneity of small extracellular vesicles and presence of non-vesicular extracellular matter have led to debate about contents and functional properties of exosomes. Here, researchers at the...
Read More »Optimisation of imaging flow cytometry for the analysis of single extracellular vesicles
Extracellular vesicles (EVs) mediate targeted cellular interactions in normal and pathophysiological conditions and are increasingly recognised as potential biomarkers, therapeutic agents and drug delivery vehicles. Based on their size and biogenesis, EVs are classified as exosomes, microvesicles and apoptotic bodies. ...
Read More »Mechanisms associated with biogenesis of exosomes in cancer
Intercellular communication between cellular compartments within the tumor and at distant sites is critical for the development and progression of cancer. Exosomes have emerged as potential regulators of intracellular communication in cancer. Exosomes are nanovesicles released by cells that contain ...
Read More »Exosome-transferred lncRNAs at the core of cancer bone lesions
Exosome-mediated transfer of regulatory RNAs is a key feature that enables cancer cells to shape a tumor-promoting environment. Cancers growing in the bone can use this communication modality to...
Read More »Aspirin inhibits hypoxia-mediated lung cancer cell stemness and exosome function
Epidemiological studies have illustrated that regular aspirin consumption may decrease the risk of non-small cell lung cancer (NSCLC). Zhujiang Hospital researchers investigated the mechanism of aspirin-induced inhibition of NSCLC development during hypoxia. A549 cells were pre-treated with the vehicle control ...
Read More »Transcriptome of Extracellular Vesicles – State-of-the-Art
Exosomes and microvesicles are two major categories of extracellular vesicles (EVs) released by almost all cell types and are highly abundant in biological fluids. Both the molecular composition of...
Read More »Extracellular Vesicles from Thyroid Carcinoma – The New Frontier of Liquid Biopsy
The diagnostic approach to thyroid cancer is one of the most challenging issues in oncology of the endocrine system because of its high incidence...
Read More »Exosomes isolation and identification from equine stem cells
Mesenchymal stem cells are used for different therapeutic approaches, e.g. for osteoarthritis, lesions of the tendon as well as for bone defects...
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