Graphene-based materials are intriguing nanomaterials with applications ranging from nanotechnology-related devices to drug delivery systems and biosensing. Multifunctional graphene platforms were proposed for the detection of several...
Read More »Biogenesis, biologic function and clinical potential of exosomes in different diseases
Exosomes are extracellular vesicles (EVs) belonging to the nanovesicles family that function as signaling molecules between cells. After their first description in the late 1960s, interest in their potential as a research target has steadily increased. They are small...
Read More »Technologies and standardization in research on extracellular vesicles
Extracellular vesicles (EVs) are phospholipid bilayer membrane-enclosed structures containing RNAs, proteins, lipids, metabolites, and other molecules, secreted by various cells into physiological fluids...
Read More »Engineered extracellular vesicles/exosomes as a new tool against neurodegenerative diseases
Neurodegenerative diseases are commonly generated by intracellular accumulation of misfolded/aggregated mutated proteins. These abnormal protein aggregates impair the functions of...
Read More »Exosomes in hypoxia-induced remodeling of the tumor microenvironment
Exosomes are structurally and functionally pleiotropic nano-sized (∼30–150 nm in diameter) extracellular vesicles (EVs) with endosomal origin. These vesicles are secreted by almost all cells and play a significant role in intercellular communication...
Read More »Shedding light on the role of extracellular vesicles in HIV infection and wound healing
Extracellular vesicles (EVs) play an important role in intercellular communication. They are naturally released from cells into the extracellular environment. Based on their biogenesis, release pathways, size, content, and function, EVs are classified into exosomes, microvesicles (MVs), and apoptotic bodies ...
Read More »Cells for Cells and Austrianova publish a novel method to produce stem cell exosomes
Austrianova and Cells for Cells have just jointly published a ground breaking, peer reviewed, scientific publication on a novel, cost and time-saving method to generate extra-cellular vesicles (EVs) from encapsulated Mesenchymal Stem Cells...
Read More »High-resolution imaging flow cytometry reveals impact of incubation temperature on labeling of extracellular vesicles with antibodies
Extracellular vesicles (EVs) are released from basically all cells. Over the last decade, small EVs (sEVs; 50-150 nm) have gained enormous attention in diagnostics and therapy. However, methodological limitations coupled to the lack of EV standards leave...
Read More »Tangential flow microfluidics for the capture and release of nanoparticles and extracellular vesicles
Membranes have been used extensively for the purification and separation of biological species. A persistent challenge is the purification of species from concentrated feed solutions such as extracellular...
Read More »Proteomic and post-translational modification profiling of exosome-mimetic nanovesicles compared to exosomes
Issues associated with upscaling exosome production for therapeutic use may be overcome through utilizing artificial exosomes. Cell-derived mimetic nanovesicles (M-NVs) are a potentially...
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