The discovery that all cells secrete extracellular vesicles (EVs) to shuttle proteins and nucleic acids to recipient cells suggested they play an important role in intercellular communication. EVs are widely distributed in many body fluids, including blood, cerebrospinal fluid, urine ...
Read More »Exosomes and exRNA – Modulating Cellular Transcriptome and Regeneration
Susmita Sahoo from the Icahn School of Medicine at Mount Sinaiin New York City presents her lab’s work studying the role of exosomes and exRNA in heart...
Read More »An NGS based approach to identify exosomes mediated cell-to-cell communication
Exosomes and other extracellular vesicles (EVs) have emerged as an important mechanism of cell-to-cell communication. However, previous studies either did not fully resolve what genetic materials were shuttled by exosomes or only focused on a specific set of...
Read More »9th ExRNA Communications Consortium Investigators’ Meeting
November 6-7th, 2017 Registration* Opens: August 2017 For more info check out: exRNA.org Scientific Topics and Areas of Interest: EV Biogenesis and Function exRNA and EV Standards exRNA based Biomarkers and Therapeutics Cutting-edge Technologies exRNA/EV Scientific Tools and Resources Join ...
Read More »ExRNA in Biofluids as Biomarkers for Brain Tumors
EV RNAs have tremendous clinical potential as diagnostic, subtype-defining, and prognostic biomarkers in GBM. The identification of new EV RNA targets and validation of existing EV RNA targets will be accelerated by large-scale biorepositories established for clinic sample warehousing and ...
Read More »Plasma extracellular RNA profiles in healthy and cancer patients
Extracellular vesicles are selectively enriched in RNA that has potential as disease biomarkers. To systemically characterize circulating extracellular RNA (exRNA) profiles, researchers from the Medical College of Wisconsin performed RNA sequencing analysis on plasma extracellular vesicles derived from 50 healthy ...
Read More »Free Extracellular miRNA Functionally Targets Cells by Transfecting Exosomes from Their Companion Cells
Exosome transfer of functional RNA to target cells is well described, whereas the mechanism of transfer of exRNA free of exosomes remains unclear. In the current study, a team led by researchers from Yale University School of Medicine describe extracellular ...
Read More »RNAPro•SAL – A device for rapid and standardized collection of saliva RNA and proteins
The stabilization and processing of salivary transcriptome and proteome biomarkers is a critical challenge due to the ubiquitous nature of nucleases and proteases as well as the inherent instability of these biomarkers. Furthermore, extension of salivary transcriptome and proteome analysis ...
Read More »Indian researcher gains rare US funding
from The Times of India NEW DELHI: An Indian scientist has joined a lucrative $17 million science program in Australia. The peak United States’ medical science funding body, the National Institutes of Health (NIH), launched the program last month. Australia’s ...
Read More »Standardization of sample collection, isolation and analysis methods in extracellular vesicle research
The emergence of publications on extracellular RNA (exRNA) and extracellular vesicles (EV) has highlighted the potential of these molecules and vehicles as biomarkers of disease and therapeutic targets. These findings have created a paradigm shift, most prominently in the field ...
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