Tag Archives: extracellular RNA

The discovery that all cells secrete extracellular vesicles (EVs) to shuttle proteins and nucleic acids to recipient cells suggested they play an important role in intercellular communication. EVs are widely distributed in many body fluids, including blood, cerebrospinal fluid, urine ...

The heterogeneity of small extracellular vesicles and presence of non-vesicular extracellular matter have led to debate about contents and functional properties of exosomes. Here, researchers at the...

Scientists have improved their understanding of a new form of cell-cell communication that is based on extracellular RNA (exRNA). RNA, a molecule that...

The regulation and functional roles of secreted coding and long noncoding RNAs (lncRNAs; >200 nt) are largely unknown. Researchers from the Vanderbilt University Medical Center previously showed that...

The release and uptake of nano-sized extracellular vesicles (EV) is a highly conserved means of intercellular communication. The molecular composition of EV, and thereby their signaling function to...

Exosomes and other extracellular vesicles (EVs) have emerged as an important mechanism of cell-to-cell communication. However, previous studies either did not fully resolve what genetic materials were shuttled by exosomes or only focused on a specific set of...

Recent years have witnessed intensive progress in studying extracellular vesicles (EVs), both for understanding their basic biology and contribution to variety of diseases, biomarker discovery, and their potential as gene delivery vectors and source of innovative therapies. As such, stem ...

To address the lack of standard terminology to describe extracellular RNA (exRNA) data/metadata, a team led by researchers at Yale University School of Medicine have launched an inter-community effort to extend the Gene Ontology (GO) with subcellular structure concepts relevant ...

Extracellular vesicles are selectively enriched in RNA that has potential as disease biomarkers. To systemically characterize circulating extracellular RNA (exRNA) profiles, researchers from the Medical College of Wisconsin performed RNA sequencing analysis on plasma extracellular vesicles derived from 50 healthy ...

Extracellular RNAs (exRNAs) found in biofluids are a rich source of information about cellular processes in both health and disease. In particular, exRNAs enclosed in extracellular vesicles and therefore protected from degradation, are involved in intercellular communication and may serve ...