The intranasal EVs-ACE2 could be a preventive medicine to protect from SARS-CoV-2 infection. This EVs-based strategy offers a potential route to...
Read More »A new blood test to detect SARS-COV-2 using extracellular vesicles
Nasal swab PCR tests are the gold standard for diagnosing COVID-19. But sometimes these tests miss cases when patients are swabbed later in the course of their infection as viral levels decline in the upper respiratory tract yet remain in ...
Read More »Extracellular RNAs as potential biomarkers for cancer
The discovery that all cells secrete extracellular vesicles (EVs) to shuttle proteins and nucleic acids to recipient cells suggested they play an important role in intercellular communication. EVs are widely distributed in many body fluids, including blood, cerebrospinal fluid, urine ...
Read More »Is size exclusion chromatography the best option for exosomal isolation?
Extracellular vesicles (EVs) are membranous vesicles secreted by both prokaryotic and eukaryotic cells and play a vital role in intercellular communication. EVs are classified into several subtypes based on their origin, physical characteristics, and biomolecular...
Read More »Different precipitation-based methods impact extracellular vesicles biomarker analysis
Extracellular vesicles(EVs) is an emerging approach of cancer liquid biopsy. Although the precipitation-based method with commercial kits has gained popularity as the second most commonly used technique, these protocols vary tremendously with many...
Read More »Breast cancer cells use message-carrying extracellular vesicles to send oncogenic stimuli to neighboring normal cells
According to a study by The Wistar Institute, breast cancer cells starved for oxygen send out messages that induce oncogenic changes in surrounding normal epithelial cells. These messages are packaged into particles called extracellular vesicles (EVs) and reprogram mitochondrial shape ...
Read More »A two-dimensional affinity capture and separation mini-platform for the isolation, enrichment, and quantification of biomarkers and its potential use for liquid biopsy
Biomarker detection for disease diagnosis, prognosis, and therapeutic response is becoming increasingly reliable and accessible. Particularly, the identification of circulating cell-free chemical and biochemical substances, cellular and subcellular entities...
Read More »Tear exosomes – a potential source of diagnostic and prognostic biomarkers for metastatic breast cancer
Exosomes are produced by normal and cancer cells. Exosomes are found in the serum of cancer patients and have been used for diagnosis and prognosis. Recently tears from non-cancer patients have been found to contain exosomes. In the present report ...
Read More »Quantum dot labeling and visualization of extracellular vesicles
Extracellular vesicles (EVs) are important mediators of intercellular communication. Their role in disease processes, uncovered mostly over the last two decades, makes them potential biomarkers, leading to a need to fundamentally understand EV biology...
Read More »MIFlowCyt-EV – a framework for standardized reporting of extracellular vesicle flow cytometry experiments
Extracellular vesicles (EVs) are small, heterogeneous and difficult to measure. Flow cytometry (FC) is a key technology for the measurement of individual particles, but its application to the analysis of EVs and other submicron particles has presented many challenges and ...
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