A joint project led by Kumamoto University (Japan) has discovered a new mechanism for anticancer drug resistance in gastric cancer. Researchers found that the Annexin A6 molecule contained in...
Read More »Researchers use exosomes to deliver antagomirs to reverse chemoresistance in gastric cancer
Chemoresistance is one of the causes of adverse effects in gastric cancer, including a poor response to cisplatin (DDP). Exosomes loaded with...
Read More »Recovery of serum exosomal microRNAs from FTA Elute cards for biomarker discovery and diagnostics
The preservation of nucleic acids from clinical samples is critical to facilitate accurate molecular diagnosis. The use of a paper matrix, Flinders Technology Associates (FTA) Elute cards, to archive DNA and viral RNA is well-documented. However, the feasibility of FTA ...
Read More »A novel anti-cancer mechanism by exosome release suppression
Poor prognosis of gastric cancer is related to not only malignancy of gastric cancer cells, but also the tumor microenvironment. Thus drugs, which can inhibit both of them, are urgently needed to be explored. Studies on effect of Proton-pump inhibitors ...
Read More »Stupid Strong awards its first research grant to fund the development of a liquid biopsy test for microRNA biomarkers
DALLAS, Feb. 18, 2016 /PRNewswire/ — Stupid Strong, a non-profit organization that raises awareness and funds for gastric cancer, is awarding its first research grant of $151,974 to fund a proposal for the development of micro-RNA biomarkers for the early detection ...
Read More »Interactions of tumour-derived micro(nano)vesicles with human gastric cancer cells
Tumour cells release membrane micro(nano)fragments called tumour-derived microvesicles (TMV) that are believed to play an important role in cancer progression. TMV suppress/modify antitumour response of the host, but there is also some evidence for their direct interaction with cancer cells. ...
Read More »Circulating microRNAs and long non-coding RNAs in gastric cancer diagnosis
Gastric cancer (GC) is the fourth most common cancer and the third leading cause of cancer mortality worldwide. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are the most popular non-coding RNAs in cancer research. To date, the roles of miRNAs ...
Read More »Diagnostic value of a plasma microRNA signature in gastric cancer: a microRNA expression analysis
The differential expression of microRNAs (miRNAs) in plasma of gastric cancer (GC) patients may serve as a diagnostic biomarker. A total of 33 miRNAs were identified through the initial screening phase (3 GC pools vs. 1 normal control (NC) pool) ...
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