Malignant melanoma (MM), the most lethal skin cancer, is highly invasive and metastatic. These qualities are related to not only genetic mutations in MM itself but also the interaction of MM cells with...
Read More »Carmine, Takeda use extracellular vesicles for rare disease gene therapies
Carmine Therapeutics announced today that it has signed a research collaboration agreement with Takeda Pharmaceutical to discover, develop and commercialize transformative non-viral gene therapies for two rare disease targets using Carmine's...
Read More »Hartwell Award researcher will pursue use of exosomes that encapsulate RNAi as an effective means to deliver cancer therapy
Soojung Claire Hur, the Clare Boothe Luce Assistant Professor of Mechanical Engineering, was selected by The Hartwell Foundation to receive a 2019 Hartwell Individual Biomedical Research Award. The award...
Read More »Carmine Therapeutics launches – a company pioneering red blood cell (RBC)-derived extracellular vesicle (EV)-based gene therapies
Esco Ventures is pleased to announce the launch of Carmine Therapeutics and execution of an exclusive license agreement for the technology developed in the laboratories of Professors Minh Leand Jiahai Shi at the City University of Hong Kong. Carmine Therapeutics plans to ...
Read More »Exosome-mimetic nanoplatforms for targeted cancer drug delivery
Lack of effective tumor-specific delivery systems remains an unmet clinical challenge for successful translation of innovative therapies, such as, therapeutic oligonucleotides. In the past decade...
Read More »Exosome-mediated horizontal gene transfer occurs in double-strand break repair during genome editing
The CRISPR-Cas9 system has been successfully applied in many organisms as a powerful genome-editing tool. Undoubtedly, it will soon be applied to human genome editing, including gene therapy. Researchers from the National Institute of Health...
Read More »Scientists at the German Primate Center improve DNA transfer in gene therapy with exosomes
Parkinson’s disease, Huntington’s disease, cystic fibrosis – these and many other fatal hereditary human diseases are genetically transmitted. Many cancers and cardiovascular diseases are also caused by genetic defects. Gene therapy is a promising possibility for the treatment of these ...
Read More »Recent advances in nanoparticle-based cancer drug and gene delivery
Effective and safe delivery of anticancer agents is among the major challenges in cancer therapy. The majority of anticancer agents are toxic to normal...
Read More »Exosomes – new molecular targets of diseases
Extracellular vesicles (EVs) comprise apoptotic bodies, microvesicles and exosomes, and they perform as key regulators in cell-to-cell communication in normal as well as diseased...
Read More »Extracellular vesicles improve gene transfer with adeno-associated virus vectors
Gene therapy, the ability to treat a disease at the level of nucleic acid, has journeyed from science fiction, to hard lessons learned from early clinical trials, to improved technologies with efficacy in patients for several diseases. Adeno-associated virus (AAV) ...
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