Tag Archives: Glioblastoma

Gliomas including glioblastoma (GBM) are the most common primary malignant brain tumors. Glioma extracellular vesicles (EVs) including exosomes have biological effects (e.g., immunosuppression) and contain tumor-specific cargo that could facilitate liquid biopsies. Mayo Clinic researchers aimed to develop a simple, ...

Non-coding RNA (ncRNA) species have emerged in as molecular fingerprints and regulators of brain tumor pathogenesis and progression. While changes in ncRNA levels have been traditionally regarded as...

Potential biomarkers could help monitor treatment response, guide clinical decisions A new microfluidic device developed by investigators at Massachusetts General Hospital (MGH) may help realize the potential of tumor-derived extracellular vesicles (EVs) – tiny lipid particles that carry molecules through ...

The role of extracellular vesicles in cancer biology has emerged as a focus of the study of great importance and has been shown to directly influence tumour development in several cancers including brain tumours, such as gliomas. Gliomas are the ...

Tumor-stromal communications impact tumorigenesis in ways that are incompletely understood. Here researchers from the MD Anderson Cancer Center show that Glioma Associated-human Mesenchymal Stem Cells (GA-hMSCs), a newly identified stromal component of glioblastoma, release exosomes that increase the proliferation and ...

Peripheral ischemia as a result of occlusive vascular disease is a widespread problem in patients over the age of 65. Angiogenic therapies that can induce microvascular growth have great potential for providing a long lasting solution for patients with ischemia ...

Peripheral ischemia as a result of occlusive vascular disease is a widespread problem in patients over the age of 65. Angiogenic therapies that can induce microvascular growth have great potential for providing a long lasting solution for patients with ischemia ...

Difference in size between circulating tumor and healthy DNA could be turned to an advantage SALT LAKE CITY – The liquid biopsy, a new type of blood test for detecting and monitoring cancer, is a welcome reprieve from typical biopsies. ...

The first blood-based cancer diagnostic to exploit free-floating exosomes became commercially available in the US on January 21. The launch of this ‘liquid biopsy’ from Exosome Diagnostics of Cambridge, Massachusetts, marks a step towards maturity for the fledgling science of ...

EV RNAs have tremendous clinical potential as diagnostic, subtype-defining, and prognostic biomarkers in GBM. The identification of new EV RNA targets and validation of existing EV RNA targets will be accelerated by large-scale biorepositories established for clinic sample warehousing and ...