Discovered in the late 1980s as an extracellular vesicle of endosomal origin secreted from reticulocytes, exosomes recently gained scientific attention due to its role in intercellular communication. Exosomes have now been identified to carry...
Read More »Exosome-Mediated Metastasis – Communication from a Distance
Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell communication via extracellular vesicles...
Read More »New pathway for cell communication discovered
Small lipid vesicles known as extracellular vesicles are of great interest to cell scientists since it has been discovered that they mediate intercellular communication. Now, Professor Tom Carter’s...
Read More »The Role of Exosomes on Colorectal Cancer
Exosomes are extracellular microvesicles released from cells, which are involved in many biological and pathological processes, mainly due to their role in intercellular communication. Exosomes derived from colorectal cancer (CRC) cells are related to oncogenesis, tumor cell survival, chemo-resistance and ...
Read More »Plant extracellular vesicles are incorporated by a fungal pathogen and inhibit its growth
Extracellular vesicles (EV) are membrane particles released by cells into their environment and are considered to be key players in intercellular communication. EV are produced by all domains of life but limited knowledge about EV in plants is available, although ...
Read More »A transwell assay that excludes exosomes for assessment of tunneling nanotube-mediated intercellular communication
Tunneling nanotubes (TNTs) are naturally-occurring filamentous actin-based membranous extensions that form across a wide spectrum of mammalian cell types to facilitate long-range intercellular communication. Valid assays are needed to accurately assess the downstream effects of TNT-mediated transfer of cellular signals ...
Read More »Evolutionarily Conserved Mediators of Intercellular Communication
Extracellular vesicles (EV) are sub-micron circulating vesicles found in all bodily fluids and in all species so far tested. They have also recently been identified in seawater and it has further been shown that they are released from microorganisms and ...
Read More »Exosomes as Reconfigurable Therapeutic Systems
Historically, small molecules, including steroid hormones and cytokines, have been attributed a role in paracrine and endocrine signaling, and now include a new player: biological nanoparticles, or ‘exosomes’. Generated intracellularly, and defined simply as nanoparticulate packages of signaling moieties, exosomes ...
Read More »Exosomes and MicroRNAs – Novel Modulators of Asthma and Allergy
Intercellular communication is crucial to the immune system response. In the recent years, the discovery of exosomes has changed the way immune response orchestration was understood. Exosomes are able to operate as independent units that act as mediators in both ...
Read More »Extracellular vesicles – Novel promising delivery systems for therapy of brain diseases
Extracellular vesicles (EVs) are cell-derived membrane vesicles virtually secreted by all cells, including brain cells. EVs are a major term that includes apoptotic bodies, microvesicles and exosomes. The release of EVs has been recognized as an important modulator in cross-talking ...
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