Therapeutic efficacy of the mesenchymal stromal cell (MSC), a multipotent progenitor cell, is attributed to small (50 to 200 nm) extracellular vesicles (EVs). The presence of a lipid membrane differentiates exosomes and EVs from other macromolecules. Analysis of this lipid ...
Read More »Extracellular vesicles – lipids as key components of their biogenesis and functions
Intercellular communication has been known for decades to involve either direct contact between cells or to operate by spreading molecules such as,,,
Read More »Methylcellulose-based method for visualization of exosomes
Synthetic and naturally occurring lipid-rich nanoparticles are of wide ranging importance in biomedicine. They include liposomes, bicelles, nanodiscs, exosomes and virus particles. The quantitative study of these particles requires methods for high-resolution visualization of the whole population. One powerful imaging ...
Read More »RNA in extracellular vesicles
Cells release a range of membrane-enclosed extracellular vesicles (EVs) into the environment. Among them, exosomes and microvesicles (collectively measuring 40-1000 nm in diameter) carry proteins, signaling lipids, and nucleic acids from donor cells to recipient cells, and thus have been ...
Read More »Researchers investigate the potential use of lipids in urinary exosomes as prostate cancer biomarkers
Exosomes have recently appeared as a novel source of noninvasive cancer biomarkers, since these nanovesicles contain molecules from cancer cells and can be detected in biofluids. Researchers from the Oslo University Hospital have investigated the potential use of lipids in ...
Read More »Mass spectrometry of extracellular vesicles
A brief summary of the main features of extracellular vesicles, a joint terminology for exosomes, microvesicles, and apoptotic vesicles. These vesicles are in the center of interest in biology and medical sciences, and form a very active field of research. ...
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