Exosome-mediated transfer of regulatory RNAs is a key feature that enables cancer cells to shape a tumor-promoting environment. Cancers growing in the bone can use this communication modality to...
Read More »Diverse long RNAs are differentially sorted into extracellular vesicles secreted by colorectal cancer cells
The regulation and functional roles of secreted coding and long noncoding RNAs (lncRNAs; >200 nt) are largely unknown. Researchers from the Vanderbilt University Medical Center previously showed that...
Read More »Bioengineered extracellular vesicle-mimetic nanovesicles can serve as a powerful instrument to effectively deliver lncRNA
Diabetic wounds, one of the most enervating complications of diabetes mellitus, affect millions of people worldwide annually. Vascular insufficiency, caused by hyperglycemia, is one of the primary causes...
Read More »exoRBase – a database of circRNA, lncRNA and mRNA in human blood exosomes
Exosomes, which are nanosized endocytic vesicles that are secreted by most cells, contain an abundant cargo of different RNA species that can modulate...
Read More »The decade of exosomal long RNA species
Exosomes have emerged as a novel approach for the treatment and diagnosis of cancer after RNA content was discovered in exosomes in 2007. As important meditators of intercellular communication, exosomes have become a strong focus of investigation for researchers in ...
Read More »A comparative analysis of lncRNAs in prostate cancer exosomes and their parental cell lines
Prostate cancer is the second leading cancer in men world-wide. Due to its heterogeneous nature, a considerable amount of research effort has been dedicated in identifying effective clinical biomarkers with a focus on proteins, messenger RNA and microRNAs. However, there ...
Read More »Exosomal Long Noncoding RNAs are Differentially Expressed in Cervical Cancer Patient Samples
As the second leading cause of cancer morbidity and death in women, cervical cancer remains an important public health problem worldwide. Novel biomarkers with high sensitivity and specificity for the early detection and diagnosis of cervical cancer are urgently needed. ...
Read More »lncRNA in urinary exosomes may serve as biomarkers for bladder cancer
Exosomes are 30-150nM membrane-bound secreted vesicles that are readily isolated from biological fluids such as urine (UEs). Exosomes contain proteins, micro RNA (miRNA), messenger RNA (mRNA), and long non-coding RNA (lncRNA) from their cells of origin. Although miRNA, protein and ...
Read More »Exosomal long non-coding RNA (lncRNA) in Lung Cancer
Exosomal long non-coding RNA (lncRNA) in Lung Cancer. GH Kloecker, M.D.1, N. Vinayek, M.D. 1, CG Taylor, Ph.D.2, DD Taylor, M.D.2. Departments of …
Read More »Extracellular Vesicle-Mediated Transfer of a Novel Long Noncoding RNA TUC339
Although the expression of long noncoding RNA (lncRNA) is altered in hepatocellular cancer (HCC), their biological effects are poorly defined. Researchers at the Mayo Clinic have identified lncRNA with highly conserved sequences, ultraconserved lncRNA (ucRNA) that are transcribed and altered ...
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