Tag Archives: macrophage

Obesity is a global public health issue with serious health consequences and rising prevalence. It is a risk factor for a broad range of diseases, particularly atherosclerosis and cardiovascular disease. Long-term weight loss is difficult to achieve, even with diet, ...

Tumor-derived exosomes play important roles in tumor metastases. In this report, researchers at Gifu University School of Medicine observed the fate of tumor-derived exosomes in pancreatic cancer metastatic nude-mouse models using color-coded imaging...

Macrophages are key participants in melanoma growth and survival. In general, macrophages can be classified as M1 or M2 activation phenotypes. Increasing evidence demonstrates that melanoma exosomes also facilitate tumor survival and metastasis. However, the role of melanoma exosomes in ...

Exosomes are nano vesicles secreted by cells, and contain various molecules including protein, lipid and DNA/RNA. They are crucial mediators of the intercellular communication and serve as promising vehicles for drug delivery and gene therapy. Recently, accumulating evidence suggest that ...

Unconventional secretion and subsequent uptake of molecular cargo via extracellular vesicles (EVs) is an important mechanism by which cells can exert paracrine effects. While this phenomenon has been widely characterized in the context of their ability to promote inflammation, less ...

Exosomes known as nano-sized extracellular vesicles attracted recent interests due to their potential usefulness in drug delivery. Amid remarkable advances in biomedical applications of exosomes, it is crucial to understand in vivo distribution and behavior of exosomes. Here, researchers from ...

Exosomes were small vesicles secreted by many cells, and they can play an important role in cell signal transductions. Because the diameter of exosomes is about 30-100 nm, it is so difficult to collection them. In this paper, three kinds ...