Loss of an important tumor-suppressing gene allows head and neck cancer to spin off signals to nearby nerves, changing their function and recruiting...
Read More »Generation and testing of clinical-grade exosomes for pancreatic cancer
Exosomes are extracellular vesicles produced by all cells with a remarkable ability to efficiently transfer genetic material, including exogenously loaded siRNA, to cancer cells. Here, researchers at MD Anderson Cancer Center report on a bioreactor-based...
Read More »Exosomes modulate immune responses in cancer
Exosomes are promising tools for improving cancer care, but conversely may also contribute to tumor progression. Researchers at MD Anderson Cancer Center highlight recently discovered roles of exosomes in modulating immune responses in cancer, with emphasis on exosomal surface proteins and on ...
Read More »Exosomes transfer specific miRNA that enhance the aggressiveness of glioblastoma
Tumor-stromal communications impact tumorigenesis in ways that are incompletely understood. Here researchers from the MD Anderson Cancer Center show that Glioma Associated-human Mesenchymal Stem Cells (GA-hMSCs), a newly identified stromal component of glioblastoma, release exosomes that increase the proliferation and ...
Read More »Liquid biopsies results compared with clinical outcomes
Exosome Diagnostics, Inc., and MD Anderson Cancer Center had a unique study published in Clinical Cancer Research, a peer reviewed publication of the American Association of Clinical Cancer Research. The analysis directly compared Exosome Diagnostics’ ExoLution® Plus platform with two ...
Read More »Liquid Biopsy Test Identifies Androgen Receptor Protein Expression in Circulating Tumor Cells in Women with Metastatic Breast Cancer
Epic Sciences along with researchers at the MD Anderson Cancer Center (MDA) have recently published their findings on androgen receptor (AR) protein expression in circulating tumor cells (CTCs) in patients with metastatic breast cancer in PLOS One. The publication, the ...
Read More »Surfaceome profiling enables isolation of cancer-specific exosomal cargo in liquid biopsies from pancreatic cancer patients
Detection of circulating tumor DNA (ctDNA) can be limited due to their relative scarcity in circulation, particularly while patients are actively undergoing therapy. Exosomes provide a vehicle through which cancer-specific material can be enriched from the compendium of circulating non-neoplastic ...
Read More »MD Anderson and Guardant Health announce partnership to make comprehensive liquid biopsy part of oncology standard of care
The University of Texas MD Anderson Cancer Center and Guardant Health today announced a multi-year partnership designed to accelerate comprehensive liquid biopsy technology into the standard of care in cancer treatment. The commercial, research and development agreement will make MD ...
Read More »Minimally invasive genomic and transcriptomic profiling of visceral cancers by next-generation sequencing of circulating exosomes
The ability to perform comprehensive profiling of cancers at high-resolution is essential for precision medicine. Liquid biopsies using shed exosomes provide high-quality nucleic acids to obtain molecular characterization, which may be especially useful for visceral cancers that are not amenable ...
Read More »Benchtop isolation and characterization of functional exosomes by sequential filtration
Early and minimally invasive detection of malignant events or other pathologies is of utmost importance in the pursuit of improved patient care and outcomes. Recent evidence indicates that exosomes and extracellular vesicles in serum and body fluids can contain nucleic ...
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