Tag Archives: Melanoma

Macrophages are key participants in melanoma growth and survival. In general, macrophages can be classified as M1 or M2 activation phenotypes. Increasing evidence demonstrates that melanoma exosomes also facilitate tumor survival and metastasis. However, the role of melanoma exosomes in ...

Exosomes are nanovesicles that are released from normal and tumor cells and are detectable in cell culture supernatant and human biological fluids. Although previous studies have explored exosomes released from cancer cells, little is understood regarding the functions of exosomes ...

Biocartis Group NV , an innovative molecular diagnostics company, today announces the publication in the renowned clinical oncology journal The Lancet Oncology of an important study[1] by Prof. Dr. Bart Neyns from the University Hospital in Brussels (Belgium). In this ...

Liquid biopsy of tumor through isolation of circulating tumor cells (CTCs) allows non-invasive, repetitive, and systemic sampling of disease. Although detecting and enumerating CTCs is of prognostic significance in metastatic cancer, it is conceivable that performing molecular and functional characterization ...

CAMBRIDGE, Mass.–(BUSINESS WIRE)–Exosome Diagnostics, Inc., the world’s only provider of a revolutionary liquid biopsy platform that enables analysis of both living and dying processes of disease states, thus aiming to reduce or eliminate the need for tissue biopsies, today announced ...

New research has identified a novel mode of communication between adipocytes and cancer cells that regulates tumour aggressiveness. Adipocyte exosomes (ad-exos) purified from conditioned medium of 3T3-F442A mature adipocytes increased melanoma cell migration and invasion in vitro. Analysis of the ...

New Brunswick, N.J. – The mechanism by which small cellular vesicles promote melanoma metastasis (spread of disease), will be further explored by investigators at Rutgers Cancer Institute of New Jersey and the Ernest Mario School of Pharmacy at Rutgers University. A ...

Uveal melanoma is a tumour arising from melanocytes of the eye, and 30 per cent of these patients develop liver metastases. Exosomes are small RNA containing nano-vesicles released by most cells, including malignant melanoma cells. This clinical translational study included ...

Exosomes are cell derived extracellular nanovesicles that relay molecular signals pertinent to both normal physiologic and disease processes. The ability to modify and track exosomes in vivo is essential to understanding exosome pathogenesis, and for utilizing exosomes as effective diagnostic ...

Malignant melanoma is an aggressive tumor that produces exosomes, which contain microRNAs (miRNAs) that could be of utility in following tumoral cell dysregulation. MicroR-125b is a miRNA whose down-regulation seems to be implicated in melanoma progression. Serum samples were obtained ...