Exosomes are extracellular vesicles (EVs) belonging to the nanovesicles family that function as signaling molecules between cells. After their first description in the late 1960s, interest in their potential as a research target has steadily increased. They are small...
Read More »Intranasal delivery of Mesenchymal Stem Cells provides hope for treating Alzheimer’s disease
In the search for a cure for Alzheimer's disease, mesenchymal stem cells and their derived extracellular vesicles (MSC-EVs) offer much promise, thanks to their protective and anti-inflammatory properties. The results from a new study done on mice...
Read More »Novel applications of MSC-derived exosomes for myocardial infarction therapeutics
Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity globally, representing approximately a third of all deaths...
Read More »Extracellular vesicles – potential role in osteoarthritis regenerative medicine
Osteoarthritis (OA) is a prevalent whole joint disease characterised by cartilage degradation, subchondral bone sclerosis and bone remodelling, and synovium inflammation, leading to pain, deformity, and cartilage dysfunction. Currently, there is no appropriate therapy for OA, and available treatments simply ...
Read More »Promise of extracellular vesicles for diagnosis and treatment of epilepsy
Extracellular vesicles (EVs) released from cells play vital roles in intercellular communication. Moreover, EVs released from stem cells have therapeutic properties. Researchers from Texas A&M University College of Medicine discuss the potential of brain...
Read More »Mesenchymal stem cell exosomes – a two-edged sword in cancer therapy
Mesenchymal stem cells (MSCs) are multipotent stromal cells present in various adult tissues. Several studies suggest that MSCs secrete exosomes that...
Read More »Extracellular vesicles from human stem cells can alleviate cellular aging in culture
Extracellular vesicles (EVs), including exosomes and microvesicles, mediate intercellular communications and exert various biological activities via delivering unique cargos of functional molecules such as proteins to recipient cells. Previous studies showed that EVs produced and secreted by human mesenchymal stem ...
Read More »Stem cell extracellular vesicles in skin repair
Stem cell extracellular vesicles (EVs) have been widely studied because of their excellent therapeutic potential. EVs from different types of stem cell can improve vascularization as well as aid in the treatment of cancer and neurodegenerative diseases. The skin is ...
Read More »Engineering mesenchymal stem cells to improve their exosome efficacy and yield for cell-free therapy
Through traditional medicine, there were diseases and disorders that previously remained untreated or were simply thought to be incurable. Since the discovery of mesenchymal stem cells (MSCs), there has...
Read More »Extracellular vesicles in the hematopoietic microenvironment
Self-renewal and differentiation are defining characteristics of hematopoietic stem and progenitor cells, and their balanced regulation is central to lifelong function of both blood and immune systems. In addition to cell intrinsic programs, hematopoietic stem and progenitor cells fate decisions ...
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