Tumor-secreted extracellular vesicles (EVs) are the main mediators of cell-cell communication, permitting cells to exchange proteins, lipids, and...
Read More »The Role of Exosomes in Metastasis and Progression of Melanoma
The mechanisms of melanoma metastasis have been the subject of extensive research for decades. Improved diagnostic and therapeutic strategies are...
Read More »Decoding the Biology of Exosomes in Metastasis
Metastasis is the leading cause of cancer mortality. Cancer cells must adapt to colonize and thrive at the metastatic site. The modulation of the receptive organ microenvironment is a key event in the adaptation process and is partially accomplished at ...
Read More »Communication in tiny packages – Exosomes as means of tumor-stroma communication
Tumor-derived exosomes are nano-sized vesicles acting as multi-signal devices influencing tumor growth at local and distant sites. Exosomes are derived from the endolysosomal compartment and can shuttle diverse biomolecules like nucleic acids (microRNAs, DNA fragments), lipids, proteins and even pharmacological ...
Read More »Osteosarcoma cell lines may selectively package miRNAs as molecular cargo of extracellular vesicles
Osteosarcoma is the most common primary bone tumor during childhood and adolescence. Several reports have presented data on serum biomarkers for osteosarcoma, but few reports have analyzed...
Read More »Exosome-Mediated Metastasis – Communication from a Distance
Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell communication via extracellular vesicles...
Read More »Extracellular Vesicles and carried miRNAs in the progression of renal cell carcinoma
The formation and maintenance of renal cell carcinomas (RCC) involve many cell types, such as cancer stem and differentiated cells, endothelial...
Read More »Exosomal miRNAs from highly metastatic cells can induce metastasis in non-metastatic cells
Breast cancer is a high prevalence cancer among women worldwide. 15-20% of breast cancer cases are triple-negative with a poor prognosis. miRNA aberrant expression is one of the reasons of cancer development and metastasis. Exosomes are vesicles...
Read More »From microfluidics to metastasis – New platform enables longitudinal studies of circulating tumor cells in mouse models of cancer.
MIT researchers’ new platform detects and extracts rare circulating tumor cells from live mouse models using a combination of laser excitation and a microfluidic chip. Circulating tumor cells (CTCs) — an intermediate form of cancer cell between a primary and ...
Read More »An interferon-driven oxysterol-based defense against tumor-derived extracellular vesicles
Tumor-derived extracellular vesicles (TEV) “educate” healthy cells to promote metastases. Researchers from the University of Pennsylvania found that melanoma TEV downregulated type I interferon (IFN)...
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