Poor prognosis of gastric cancer is related to not only malignancy of gastric cancer cells, but also the tumor microenvironment. Thus drugs, which can inhibit both of them, are urgently needed to be explored. Studies on effect of Proton-pump inhibitors ...
Read More »Digital Detection of Exosomes by Interferometric Imaging
Exosomes, which are membranous nanovesicles, are actively released by cells and have been attributed to roles in cell-cell communication, cancer metastasis, and early disease diagnostics. The small size (30-100 nm) along with low refractive index contrast of exosomes makes direct characterization ...
Read More »Bovine milk exosomes contain microRNA and mRNA and are taken up by human macrophages
Researchers from the Morinaga Milk Industry Co, Japan reported previously that microRNA (miRNA) are present in whey fractions of human breast milk, bovine milk, and rat milk. Moreover, they confirmed that many mRNA species are present in rat milk whey. ...
Read More »Integrated systems for exosome investigation
Extracellular vesicles, including exosomes, are currently being investigated to better understand their biogenesis and biological functions. There is also a rapidly growing interest in utilizing exosomes present in patient biofluids for molecular diagnostics in the clinic. Exosomes are natural shuttles ...
Read More »Purification of Human Urinary Extracellular Vesicles Directly from Urine Samples
As cellular-derived vesicles largely maintain the biomolecule composition of their original tissue, exosomes, which are found in nearly all body fluids, have enormous potential as clinical disease markers. A major bottleneck in the development of exosome-based diagnostic assays is the ...
Read More »Urinary Exosome miRNome Analysis and its Applications to Salt Sensitivity of Blood Pressure
Salt sensitivity of blood pressure (BP) is associated with higher incidence of cardiovascular disease independent of hypertension: however, it is difficult to diagnose. The paradoxical decrease in BP following high salt intake, which we term “inverse salt sensitivity” also may ...
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