Researchers at the Chinese Academy of Sciences have developed an exosome isolation and detection method based on a microfluidic device (ExoDEP-chip), which realized microsphere mediated...
Read More »Exosome trapping and enrichment using a sound wave activated nano-sieve (SWANS)
Exosomes, a form of extracellular vesicle, are an important precursor in regenerative medicine. Microfluidic methods exist to capture these sub-micrometer sized objects from small quantities of sample, ideal for multiple diagnostic applications...
Read More »Sensor-integrated microfluidic approaches for liquid biopsies applications in early detection of cancer
Cancer represents one of the conditions with the most causes of death worldwide. Common methods for its diagnosis are based on tissue biopsies-the extraction of tissue from the primary tumor, which is used for its histological analysis. However, this technique ...
Read More »Microfluidic device for on-chip isolation and detection of circulating exosomes in blood of breast cancer patients
Tumor-derived circulating exosomes have been recognized as a promising biomarker source for cancer diagnosis via a less invasive procedure. The integration of isolation and detection of exosomes in...
Read More »Microfluidic on-demand engineering of exosomes towards cancer immunotherapy
Extracellular Vesicles (EVs), particularly exosomes (30-150 nm), are an emerging delivery system in mediating cellular communications, which have been observed for priming immune responses by presenting parent cell signaling proteins or tumor antigens...
Read More »The use of microfluidic technology for cancer applications and liquid biopsy
There is growing awareness for the need of early diagnostic tools to aid in point-of-care testing in cancer. Tumor biopsy remains the conventional means in which to sample a tumor and often presents with challenges and associated risks. Therefore...
Read More »Whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells
Precise rare-cell technologies require the blood to be processed immediately or be stabilized with fixatives. Such restrictions limit the translation of circulating tumor cell (CTC)-based liquid biopsy assays that provide accurate molecular data in guiding clinical decisions. Here researchers from ...
Read More »Clinical Applications of NanoVelcro Rare-Cell Assays for Detection and Characterization of Circulating Tumor Cells
Liquid biopsy of tumor through isolation of circulating tumor cells (CTCs) allows non-invasive, repetitive, and systemic sampling of disease. Although detecting and enumerating CTCs is of prognostic significance in metastatic cancer, it is conceivable that performing molecular and functional characterization ...
Read More »Ultrasensitive Microfluidic Analysis of Circulating Exosomes Using Nanostructured Graphene Oxide/Polydopamine Coating
Exosomes are cell-derived nanosized vesicles that have been recently recognized as new mediators for many cellular processes and potential biomarkers for non-invasive disease diagnosis and monitoring of treatment response. To better elucidate the biology and clinical value of exosomes, there ...
Read More »A Microfluidic ExoSearch Chip for Multiplexed Exosome Detection Towards Blood-based Ovarian Cancer Diagnosis
Tumor-derived circulating exosomes, enriched with a group of tumor antigens, have been recognized as a promising biomarker source for cancer diagnosis via less invasive procedure. Quantitatively pinpointing exosome tumor markers is appealing, yet challenging. The sequential snapshots showing the release ...
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