Extracellular vesicles (EVs) are membranous vesicles secreted by both prokaryotic and eukaryotic cells and play a vital role in intercellular communication. EVs are classified into several subtypes based on their origin, physical characteristics, and biomolecular...
Read More »A microfluidic device for detection and isolation of lung cancer-specific exosomes from urine
Exosomes, derived from various biofluids, may serve as potential biomarkers for cancer early detection. Nevertheless, exosome clinical translation remains...
Read More »Microfluidic Technology for Clinical Applications of Exosomes
Exosomes, a type of nanovesicle, are distinct cellular entities specifically capable of carrying various cargos between cells. It has been hypothesized that exosomes, as an enriched source of biomolecules...
Read More »Lab-on-chip for exosomes and microvesicles detection and characterization
Interest in extracellular vesicles and in particular microvesicles and exosomes, which are constitutively produced by cells, is on the rise for their huge...
Read More »From microfluidics to metastasis – New platform enables longitudinal studies of circulating tumor cells in mouse models of cancer.
MIT researchers’ new platform detects and extracts rare circulating tumor cells from live mouse models using a combination of laser excitation and a microfluidic chip. Circulating tumor cells (CTCs) — an intermediate form of cancer cell between a primary and ...
Read More »Microfluidics-based on-a-chip systems for isolating and analysing extracellular vesicles
Extracellular vesicles (EVs), which can be found in almost all body fluids, consist of a lipid bilayer enclosing proteins and nucleic acids from their...
Read More »Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems
Lipid-based nanobiomaterials as liposomes and lipid nanoparticles (LNPs) are the most widely used nanocarriers for drug delivery systems (DDSs). Extracellular vesicles (EVs) and exosomes are also...
Read More »Microfluidics technologies for blood-based cancer liquid biopsies
Blood-based liquid biopsies provide a minimally invasive alternative to identify cellular and molecular signatures that can be used as biomarkers to detect early-stage cancer, predict disease progression, longitudinally monitor response to chemotherapeutic drugs, and provide personalized treatment options. Specific targets ...
Read More »Blood testing via sound waves may replace some tissue biopsies
Microfluidic device uses acoustics to quickly analyze blood for signatures of cancer and other diseases Cells secrete nanoscale packets called exosomes that carry important messages from one part of the body to another. Scientists from MIT and other institutions ...
Read More »Separation of extracellular nanovesicles and apoptotic bodies from cancer cell culture broth using tunable microfluidic systems
Extracellular vesicles (EVs) are the cell-secreted nano- and micro-sized particles consisted of lipid bilayer containing nucleic acids and proteins for diagnosis and therapeutic applications. The inherent complexity of EVs is a source of heterogeneity in various potential applications of the ...
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