Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle vesicles...
Read More »Roche to apply PureTech exosomes platform for the oral administration of antisense oligonucleotides
PureTech Health, a clinical-stage biopharmaceutical company developing novel medicines focused on the Brain-Immune-Gut (BIG) Axis, today announced that it has entered into a multiyear collaboration with...
Read More »A method for isolation and enrichment of purified bovine milk exosomes
Exosomes are nanovesicles that play important roles in intercellular communication as they carry information to target cells. Isolation of high purity exosomes will aid in studying the exosomal cargo and quantity as well as how cell-specific messages are carried. Researchers ...
Read More »siRNA in milk exosomes is resistant to digestion and cross intestinal barrier in vitro
Milk is not only a composite of nutrients but emerged as a source of exosomes acting as a promising drug delivery vehicle for siRNA. siRNA is known for its immense therapeutic potential but has various physiological limitations including stable delivery. ...
Read More »Exosomal microRNAs in giant panda (Ailuropoda melanoleuca) breast milk
The physiological role of miRNAs is widely understood to include fine-tuning the post-transcriptional regulation of a wide array of biological processes. Extensive studies have indicated that exosomal miRNAs in the bodily fluids of various organisms can be transferred between living ...
Read More »Milk-derived exosomes for oral delivery of cancer drugs
In this report milk-derived exosomes have been investigated for oral delivery of the chemotherapeutic drug paclitaxel (PAC) as an alternative to conventional i.v. therapy for improved efficacy and reduced toxicity. PAC-loaded exosomes (ExoPAC) were found to have a particle size ...
Read More »Breast milk-derived exosomes promote intestinal epithelial cell growth
Breast milk administration prevents necrotizing enterocolitis (NEC). However, the mechanism remains unclear. Exosomes are cell-derived vesicles highly present in human milk and regulate intercellular signaling, inflammation, and immune response. Researchers from The Hospital for Sick Children hypothesized that milk-derived exosomes ...
Read More »Dairy cow milk microRNAs associated with exosomes can resist digestion
MicroRNAs are small, gene-regulatory noncoding RNA species present in large amounts in milk, where they seem to be protected against degradative conditions, presumably because of their association with exosomes. Researchers from the University of Quebec monitored the relative stability of ...
Read More »Bovine milk exosomes contain microRNA and mRNA and are taken up by human macrophages
Researchers from the Morinaga Milk Industry Co, Japan reported previously that microRNA (miRNA) are present in whey fractions of human breast milk, bovine milk, and rat milk. Moreover, they confirmed that many mRNA species are present in rat milk whey. ...
Read More »Bovine microRNA passed to human cells through milk exosomes
Researchers from the Morinaga Milk Industry Co reported previously that microRNA (miRNA) are present in whey fractions of human breast milk, bovine milk, and rat milk. Moreover, they also confirmed that so many mRNA species are present in rat milk ...
Read More »