Researchers from Southern Methodist University describes a method to gauge the stiffness of nanosized liposomes – a nanoscale vesicle – using a custom-made recapture platform coupled to a...
Read More »Recent advances in nanoparticle-based cancer drug and gene delivery
Effective and safe delivery of anticancer agents is among the major challenges in cancer therapy. The majority of anticancer agents are toxic to normal...
Read More »EXPLORs – exosomes for protein loading via optically reversible protein-protein interactions
Nanoparticle-mediated delivery of functional macromolecules is a promising method for treating a variety of human diseases. Among nanoparticles, cell-derived exosomes have recently been highlighted as a new therapeutic strategy for the in vivo delivery of nucleotides and chemical drugs. Here, ...
Read More »You’ve been doing your exosome isolation all wrong
Exosomes attract enormous research interest because they are carriers of disease markers and a prospective delivery system for therapeutic agents. Differential centrifugation, the prevalent method of exosome isolation, frequently produces dissimilar and improper results because of the faulty practice of ...
Read More »Microvesicles – Isolation, Characterization for In Vitro and In Vivo Procedures
Microvesicles and exosomes are released to the extracellular milieu and are detectable in body fluids. They act as unique vehicles for cargo transfer to other cells/tissues. They contain a set of membrane receptors, intracellular proteins and nucleic acids. Here, the ...
Read More »Exosomes – Implications in HIV-1 Pathogenesis
Exosomes are membranous nanovesicles of endocytic origin that carry host and pathogen derived genomic, proteomic, and lipid cargos. Exosomes are secreted by most cell types into the extracellular milieu and are subsequently internalized by recipient cells. Upon internalization, exosomes condition ...
Read More »Exosomes as Immunotheranostic Nanoparticles
Exosomes are small biological membrane vesicles that measure 30 to 100 nm in diameter. They are involved in a wide array of biological activities, such as cell-cell communication, signal transduction, transport of genetic materials, and modulation of immune response. Evidence ...
Read More »The Mayo Clinic uses Nanoparticle Tracking Analysis to Study the Behavior of Exosomes and Microvesicles
NanoSight reports on how Nanoparticle Tracking Analysis, NTA, is being used to study extracellular vesicles in the research laboratories of Dr. Gregory Gores of the Mayo Clinic in Rochester, Minnesota. The Gores Laboratory of the Mayo Clinic does basic research ...
Read More »FedExosomes: Engineering Therapeutic Biological Nanoparticles that Truly Deliver
Many aspects of intercellular communication are mediated through “sending” and “receiving” packets of information via the secretion and subsequent receptor-mediated detection of biomolecular species including cytokines, chemokines, and even metabolites. Recent evidence has now established a new modality of intercellular ...
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