Despite intensive treatment, 50% of children with high-risk neuroblastoma (HR-NB) succumb to their disease. Progression through current trials evaluating the efficacy of new treatments for children with HR...
Read More »CHLA Researcher Awarded $1.9 Million by NIH to Study Exosomes for Battling Neuroblastoma
Muller Fabbri, MD, PhD, of the Children’s Center for Cancer and Blood Diseases at Children’s Hospital Los Angeles, has been awarded $1.9 million by the National Cancer Institute of the NIH to further his research on neuroblastoma – the third most common ...
Read More »Exosome-Mediated Transfer of microRNAs Within the Tumor Microenvironment
How exosomic microRNAs (miRNAs) contribute to the development of drug resistance in the context of the tumor microenvironment has not been previously described in neuroblastoma (NBL). Coculture experiments were performed to assess exosomic transfer of miR-21 from NBL cells to ...
Read More »Exosomic miRNAs are involved in the development of drug resistance through the tumor microenvironment
LOS ANGELES (May 13, 2015)-Researchers at Children’s Hospital Los Angeles have made an important step toward finding a target in the fight against drug-resistant neuroblastoma (NBL), the most common solid malignancy found, outside of the skull, in children. Led by ...
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