Exosomes are excretory vesicles that can deliver a variety of bioactive cargo molecules to the extracellular environment. Accumulating evidence demonstrates exosome participation in intercellular communication, immune response, inflammatory...
Read More »Exosomal miRNA confers chemo resistance in ovarian cancer
Circulating miRNAs are known to play important roles in intercellular communication. However, the effects of exosomal miRNAs on cells are not fully understood. To investigate the role of exosomal...
Read More »The potential role of miRNAs and exosomes in chemotherapy in ovarian cancer
Chemoresistance is one of the major obstacles in the treatment of cancer patients. It poses a fundamental challenge to the effectiveness of chemotherapy...
Read More »Exosomes in ovarian cancer
Exosomes are nanoparticles(40-100 nm) secreted by most cells in the body, which can be isolated from several types of extracellular fluids. It has been shown that exosomes play a key role in intercellular communication and in transportation of genetic information. ...
Read More »Surface Profiling of Extracellular Vesicles Using DotScan Antibody Microarrays
DotScan antibody microarrays were initially developed for the extensive surface profiling of live leukemia and lymphoma cells. DotScan’s diagnostic capability was validated with an extensive clinical trial using mononuclear cells from the blood or bone marrow of leukemia or lymphoma ...
Read More »Angle’s liquid biopsy ovarian cancer test could beat current standard
PharmaTimes by Selina McKee – UK liquid biopsy group Angle has released trial findings that indicate its Parsortix blood test has the potential to out-perform the current standard of care in detecting ovarian cancer. The company said headline results from ...
Read More »The emerging roles and therapeutic potential of exosomes in ovarian cancer
A summary of the roles of exosomes in ovarian cancer Ovarian cancer (OC) is one of the three types of malignant tumors in the female reproductive system, and epithelial ovarian cancer (EOC) is its most typical form. Due to the ...
Read More »Proof-of-concept data for a novel exosome-based cancer detection platform published
Peregrine Pharmaceuticals, Inc., a biopharmaceutical company committed to improving patient lives by manufacturing high quality products for biotechnology and pharmaceutical companies and advancing its proprietary R&D pipeline, today announced the publication of positive proof-of-concept data for a novel exosome-based cancer detection ...
Read More »Clinical relevance of circulating cell-free microRNAs in ovarian cancer
Ovarian cancer is the leading cause of death among gynecologic malignancies. Since ovarian cancer develops asymptomatically, it is often diagnosed at an advanced and incurable stage. Despite many years of research, there is still a lack of reliable diagnostic markers ...
Read More »The biological significance and clinical applications of exosomes in ovarian cancer
Exosomes are nano-sized (20-100nm) vesicles released by a variety of cells and are generated within the endosomal system or at the plasma membrane. There is emerging evidence that exosomes play a key role in intercellular communication in ovarian and other ...
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