Tag Archives: Paclitaxel

Pancreatic ductal adenocarcinoma (PDAC) is one of the most intractable malignancy, with an only 6% 5-year relative survival rate. The dismal therapeutic effect is attributed to the chemotherapy resistance and unique pathophysiology with abundant inflammatory cytokines and abnormal hyperplasia of ...

Exosomes derived from mesenchymal stem cells (MSCs) have been evaluated for their potential to be used as drug delivery vehicles. Synthetically personalized exosome mimetics (EMs) could be the...

Exosomes are small membrane vesicles (30-100nm in diameter) secreted by cells into extracellular space. The present study evaluated the effect of chemotherapeutic agents on exosome production and/or release, and quantified the contribution of exosomes to intercellular drug transfer and pharmacodynamics. ...

Exosomes have recently emerged as a promising drug delivery system with low immunogenicity, high biocompatibility, and high efficacy of delivery. Researchers at University of North Carolina at Chapel Hill demonstrated earlier that macrophage-derived exosomes (exo) loaded with a potent anticancer ...

Cancer drugs packaged in immune bubbles home in directly to tumors without getting sidetracked and destroyed; less chemo with better results Chapel Hill, N.C. – (Jan.14, 2016) —The cancer drug paclitaxel just got more effective. For the first time, researchers ...

Exosomes have recently come into focus as “natural nanoparticles” for use as drug delivery vehicles. Researchers at the University of North Carolina at Chapel Hill set out to assess the feasibility of an exosome-based drug delivery platform for a potent ...

Extracellular vesicles (EVs) are naturally occurring membrane particles that mediate intercellular communication by delivering molecular information between cells. In this study, researchers from the University of Helsinki investigated the effectiveness of two different populations of EVs (microvesicle- and exosome-enriched) as ...