Pancreatic ductal adenocarcinoma (PDAC) is one of the most intractable malignancy, with an only 6% 5-year relative survival rate. The dismal therapeutic effect is attributed to the chemotherapy resistance and unique pathophysiology with abundant inflammatory cytokines and abnormal hyperplasia of ...
Read More »A new approach for loading anticancer drugs into mesenchymal stem cell-derived exosome mimetics
Exosomes derived from mesenchymal stem cells (MSCs) have been evaluated for their potential to be used as drug delivery vehicles. Synthetically personalized exosome mimetics (EMs) could be the...
Read More »Exosomes are a mechanism of intercellular drug transfer
Exosomes are small membrane vesicles (30-100nm in diameter) secreted by cells into extracellular space. The present study evaluated the effect of chemotherapeutic agents on exosome production and/or release, and quantified the contribution of exosomes to intercellular drug transfer and pharmacodynamics. ...
Read More »Engineering Macrophage-derived Exosomes for Targeted Paclitaxel Delivery to Pulmonary Metastases
Exosomes have recently emerged as a promising drug delivery system with low immunogenicity, high biocompatibility, and high efficacy of delivery. Researchers at University of North Carolina at Chapel Hill demonstrated earlier that macrophage-derived exosomes (exo) loaded with a potent anticancer ...
Read More »Researchers at UNC-Chapel Hill use exosomes to kill drug-resistant lung cancer with 50 times less chemo
Cancer drugs packaged in immune bubbles home in directly to tumors without getting sidetracked and destroyed; less chemo with better results Chapel Hill, N.C. – (Jan.14, 2016) —The cancer drug paclitaxel just got more effective. For the first time, researchers ...
Read More »Development of Exosome-encapsulated Paclitaxel to Overcome MDR in Cancer cells
Exosomes have recently come into focus as “natural nanoparticles” for use as drug delivery vehicles. Researchers at the University of North Carolina at Chapel Hill set out to assess the feasibility of an exosome-based drug delivery platform for a potent ...
Read More »Researchers use exosomes to control drug delivery
Extracellular vesicles (EVs) are naturally occurring membrane particles that mediate intercellular communication by delivering molecular information between cells. In this study, researchers from the University of Helsinki investigated the effectiveness of two different populations of EVs (microvesicle- and exosome-enriched) as ...
Read More »