Cancer-associated fibroblasts (CAFs) comprise the majority of the tumor bulk of pancreatic ductal adenocarcinomas (PDACs). Current efforts to eradicate these tumors focus predominantly on targeting the proliferation of rapidly growing cancer epithelial cells. We know that this is largely ineffective ...
Read More »Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis, mainly due to delayed detection. We hypothesized that intercellular communication is critical for metastatic progression. Here, researchers from the Weill Cornell Medical College show that PDAC-derived exosomes induce liver pre-metastatic ...
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