The use of disease-specific signatures of microRNAs (miRNAs) in exosomes has become promising for clinical applications, either as biomarkers or direct...
Read More »Direct isolation and characterization of circulating exosomes from biological samples using magnetic nanowires
Tumor-derived exosomes are gaining attention as important factors that facilitate communication between neighboring cells and manipulate cellular processes associated with cancer development or...
Read More »Large extracellular vesicles carry most of the tumour DNA circulating in prostate cancer patient plasma
Cancer-derived extracellular vesicles (EVs) are membrane-enclosed structures of highly variable size. EVs contain a myriad of substances (proteins, lipid, RNA, DNA) that provide a reservoir of...
Read More »Personal Genome Diagnostics’ liquid biopsy receives breakthrough device designation from FDA
Personal Genome Diagnostics, a leading cancer genomics company and pioneer in liquid biopsy, today announced that PGDx elio™ plasma resolve has received Breakthrough Device designation from...
Read More »Breast cancer exosomes isolated from plasma of stage 1 and stage 2 breast cancer patients gives the same RNA signature as matched tumor tissue
This groundbreaking observation is presented as Late Breaking Research at the AACR Annual Meeting in Chicago on Tuesday by Dr Sudipto Chakrabortty.
Read More »Plasma-derived exosome characterization reveals a distinct microRNA signature in diabetes
Type 1 diabetes mellitus (T1DM) results from an autoimmune attack against the insulin-producing ß cells which leads to chronic hyperglycemia. Exosomes are lipid vesicles derived from cellular multivesicular bodies that are enriched in specific miRNAs, potentially providing a disease-specific diagnostic ...
Read More »Plasma extracellular vesicles – a biomarker discovery platform for neurological disorders
A research team at the National Institute on Aging has been a pioneer in harvesting extracellular vesicles (EVs) enriched for neuronal origin from peripheral blood and using them as a biomarker discovery platform for neurological disorders. This methodology has demonstrated excellent diagnostic ...
Read More »Measurement of exosomal miRNAs cannot be replaced by the measurement of miRNAs in plasma
Liquid biopsies have advanced rapidly in recent years for use in diagnostic and prognostic applications. One important aspect of this advancement is the growth in our understanding of microRNA (miRNA) biology. The measurement of miRNAs packaged within exosomes, which are ...
Read More »Breakthrough discovery may make blood test feasible for detecting cancer
Doctors may soon be able to detect and monitor a patient’s cancer with a simple blood test, reducing or eliminating the need for more invasive procedures, according to Purdue University research. W. Andy Tao, a professor of biochemistry and member ...
Read More »MicroRNA Profiling of Exosomes
Exosomes are nano-sized membrane-bound vesicles released by a range of different cell types. Exosomes have been shown to specifically package certain membrane and cytosolic proteins and nucleic acids. Furthermore, it has been shown that their contents can be transferred to ...
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