Diabetes represents a major threat to public health and the number of patients is increasing alarmingly in the global scale. Particularly, the diabetic kidney disease (nephropathy, DN) together with its cardiovascular complications cause immense human suffering, highly increased risk of ...Read More »
Urinary Exosomes: A Novel Means to Non-Invasively Assess Changes in Renal Gene and Protein Expression
In clinical practice, there is a lack of markers for the non-invasive diagnosis and follow-up of kidney disease. Exosomes are membrane vesicles, which are secreted from their cells of origin into surrounding body fluids and contain proteins and mRNA which ...Read More »
Urinary exosome mRNA of CD2AP may be a non-invasive tool for detecting both renal function and fibrosis of kidney disease.
Podocyte injury plays an important role in the pathogenesis of kidney disease. Urinary exosomes are microvesicles released by tubular epithelial cells and podocytes containing information of their originated cells. This study investigated for the first time whether podocyte related mRNA ...Read More »