Tag Archives: polycystic kidney disease

Extracellular vesicles and ciliary signaling in C. elegans help reveal how an ADPKD-associated mutation disrupts polycystin protein localization...

Healthy donor extracellular vesicles and exosomes restored missing kidney proteins in ARPKD models, showing potential for prenatal treatment of severe...

Researchers at Rutgers University discovered how polycystic kidney disease proteins are packaged into extracellular vesicles, offering new insights into...

Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of ESRD. Affected individuals inherit a defective copy of either PKD1 or PKD2, which encode polycystin-1 (PC1) or polycystin-2 (PC2), respectively. PC1 and PC2 are secreted on urinary exosome-like vesicles ...

Cilia, organelles that function as cellular antennae, are central to the pathogenesis of “ciliopathies”, including various forms of polycystic kidney disease (PKD). To date, however, the molecular mechanisms controlling ciliogenesis and ciliary function remain incompletely understood. A recently proposed model ...