Tag Archives: Pre-metastatic niche

Exosomes from prostate tumors may help prepare bones for metastasis by delivering key molecules like NICD3. Understanding this process opens the door to therapies that target extracellular vesicles and could prevent prostate cancer from spreading to bone...

RNA profiling shows that extracellular vesicles from HNSCC patients reprogram macrophages to suppress immune responses and promote metastasis...

Over the past decade, extracellular vesicles and particles (EVPs) have emerged as critical mediators of intercellular communication, participating in...

Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell communication via extracellular vesicles...

Tumor-derived extracellular vesicles (TEV) “educate” healthy cells to promote metastases. Researchers from the University of Pennsylvania found that melanoma TEV downregulated type I interferon (IFN)...

While tumour cells are classically known to communicate via direct cell-to-cell contact and the secretion of soluble protein-based factors such as cytokines and growth factors, alternative novel mechanisms that promote tumour progression have recently emerged. Now, new critical components of ...

Extracellular RNA (exRNA) is functionally transferrable from donor to recipient cells and is protected from RNAses by electrostatic interactions with proteins or by membrane encapsulation. In addition to bioactive RNA, extracellular vesicles (EVs) contain intraluminal and membrane-associated proteins. The cellular ...

Exosomes are membrane-bound, intercellular communication shuttles that are defined by their endocytic origin and size range of 30-140 nm. Secreted by nearly all mammalian cell types and present in myriad bodily fluids, exosomes confer messages between cells, proximal and distal, ...

In the last decades, several studies demonstrated that the tumor microenvironment is a critical determinant not only of tumor progression and metastasis, but also of resistance to therapy. Exosomes are small membrane vesicles of endocytic origin, which contain mRNAs, DNA ...