Researchers show extracellular vesicles enable two-way RNA-based communication between gut bacteria and human colon cells, reshaping gene expression and highlighting species-specific...
Read More »Genetic tools for investigating the life cycle of extracellular vesicles
Extracellular vesicles play a crucial role in cell communication, biomarker discovery, and therapy. This review explores genetic tools for studying EV biogenesis, trafficking, and applications in...
Read More »Ultrasonication outperforms electroporation for extracellular vesicle cargo depletion
To make EVs effective for drug delivery, scientists use techniques like electroporation (EP) and ultrasonication (US) to load drugs into them...
Read More »Extracellular vesicles, RNA sequencing, and bioinformatic analyses: Challenges, solutions, and recommendations
Extracellular vesicles (EVs) are heterogeneous entities secreted by cells into their microenvironment and systemic circulation. Circulating EVs carry functional small RNAs and other molecular footprints from...
Read More »Researchers deliver siRNA in exosomes to fight Huntington’s disease
Delivery represents a significant barrier to the clinical advancement of oligonucleotide therapeutics for the treatment of neurological disorders, such as Huntington’s disease. Small, endogenous vesicles known as exosomes have the potential to act as oligonucleotide delivery vehicles, but robust and ...
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