Soojung Claire Hur, the Clare Boothe Luce Assistant Professor of Mechanical Engineering, was selected by The Hartwell Foundation to receive a 2019 Hartwell Individual Biomedical Research Award. The award...
Read More »Ras and exosome signaling
Ras gene (HRAS, NRAS, and KRAS) has been observed to be mutated and hyper-activated in a significant proportion of cancers. However, mutant Ras remains a challenging therapeutic target. Similarly, inhibition of targets upstream and downstream of Ras has shown limited ...
Read More »A paradigm shift for extracellular vesicles as small RNA carriers
RNA interference (RNAi) is an important avenue for target-specific gene silencing that is mainly performed by either small interfering RNAs (siRNAs) or microRNAs (miRNAs). This novel method is rapidly becoming a powerful tool for gene therapy. However, the rapid degradation ...
Read More »Transfer and functional consequences of dietary microRNAs in vertebrates
If validated, diet-derived foreign microRNA absorption and function in consuming vertebrates would drastically alter our understanding of nutrition and ecology. RNA interference (RNAi) mechanisms of Caenorhabditis elegans are enhanced by uptake of environmental RNA and amplification and systemic distribution of ...
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