The COVID-19 pandemic has challenged researchers to rapidly understand the capabilities of the SARS-CoV-2 virus and investigate potential therapeutics for...
Read More »Quantitative proteomics and biological activity of extracellular vesicles engineered to express SARS-CoV-2 spike protein
SARS-CoV-2 viral infection led to the devastating COVID-19 pandemic, where illness stemmed from interactions between virions and recipient host cells resulting in multi-layered pathological consequences...
Read More »ACE2-containing defensosomes serve as decoys to inhibit SARS-CoV-2 infection
Extracellular vesicles of endosomal origin, exosomes, mediate intercellular communication by transporting substrates with a variety of functions related to tissue homeostasis and disease. Their diagnostic and therapeutic potential has been recognized for...
Read More »Serum extracellular vesicles as powerful biomarkers for COVID-19 severity
COVID-19 is characterized by a wide spectrum of disease severity, whose indicators and underlying mechanisms need to be identified. The role of...
Read More »Inhalable COVID-19 vaccine of exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain
Researchers have created an inhalable COVID-19 vaccine that is shelf stable at room temperature for up to three months, targets the lungs specifically and effectively, and allows for self-administration via an inhaler. The researchers also found that the delivery mechanism ...
Read More »In long COVID, exosomal blood markers are linked to neuropsychiatric ills
In a new study of long COVID published March 13, 2022, in the Annals of Neurology, UC San Francisco researchers identified biomarkers present at...
Read More »Risk stratification of patients with SARS-CoV-2 by tissue factor expression in circulating extracellular vesicles
Inflammatory response following SARS-CoV-2 infection results in substantial increase of amounts of intravascular pro-coagulant extracellular vesicles (EVs) expressing tissue factor (CD142) on their...
Read More »Phase II IND clinical trial of combination mesenchymal stem cell and exosome treatment approved
Vitti Labs, an AATB Accredited Tissue Bank focused on life Science Research, development, and manufacturing, announced today that the U.S. Food and Drug Administration (FDA) has approved their...
Read More »Serum extracellular vesicles profiling is associated with COVID-19 progression and immune responses
Coronavirus disease 2019 (COVID-19) has transformed very quickly into a world pandemic with severe and unexpected consequences on human health. Concerted efforts to generate better diagnostic...
Read More »Engineered extracellular vesicles directed to the spike protein inhibit SARS-CoV-2
SARS-CoV-2 (CoV-2) viral infection results in COVID-19 disease, which has caused significant morbidity and mortality worldwide. A vaccine is crucial to...
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