A new clinical assay enables direct blood-based quantification of circulating SARS-CoV-2 spike protein, offering insights into long COVID, immune risk, and spike protein dynamics associated with...
Read More »Researchers identify a potential biomarker for long COVID
Researchers detected SARS-CoV-2 protein fragments within extracellular vesicles in patients with long COVID, suggesting these vesicles may harbor viral remnants. This potential biomarker could aid...
Read More »Engineered extracellular vesicles offer insight into antiviral strategies against COVID-19 variants
Engineered extracellular vesicles designed to block SARS-CoV-2 show promising antiviral activity, though effectiveness can vary between variants like...
Read More »Exploring extracellular vesicles as mediators of clinical disease and vehicles for viral therapeutics: Insights from the COVID-19 pandemic
The COVID-19 pandemic has challenged researchers to rapidly understand the capabilities of the SARS-CoV-2 virus and investigate potential therapeutics for...
Read More »Quantitative proteomics and biological activity of extracellular vesicles engineered to express SARS-CoV-2 spike protein
SARS-CoV-2 viral infection led to the devastating COVID-19 pandemic, where illness stemmed from interactions between virions and recipient host cells resulting in multi-layered pathological consequences...
Read More »ACE2-containing defensosomes serve as decoys to inhibit SARS-CoV-2 infection
Extracellular vesicles of endosomal origin, exosomes, mediate intercellular communication by transporting substrates with a variety of functions related to tissue homeostasis and disease. Their diagnostic and therapeutic potential has been recognized for...
Read More »Serum extracellular vesicles as powerful biomarkers for COVID-19 severity
COVID-19 is characterized by a wide spectrum of disease severity, whose indicators and underlying mechanisms need to be identified. The role of...
Read More »Inhalable COVID-19 vaccine of exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain
Researchers have created an inhalable COVID-19 vaccine that is shelf stable at room temperature for up to three months, targets the lungs specifically and effectively, and allows for self-administration via an inhaler. The researchers also found that the delivery mechanism ...
Read More »In long COVID, exosomal blood markers are linked to neuropsychiatric ills
In a new study of long COVID published March 13, 2022, in the Annals of Neurology, UC San Francisco researchers identified biomarkers present at...
Read More »Risk stratification of patients with SARS-CoV-2 by tissue factor expression in circulating extracellular vesicles
Inflammatory response following SARS-CoV-2 infection results in substantial increase of amounts of intravascular pro-coagulant extracellular vesicles (EVs) expressing tissue factor (CD142) on their...
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