Discovered in the late 1980s as an extracellular vesicle of endosomal origin secreted from reticulocytes, exosomes recently gained scientific attention due to its role in intercellular communication. Exosomes have now been identified to carry...
Read More »Membrane lipids define the small extracellular vesicle subtypes secreted by mesenchymal stromal cell
Therapeutic efficacy of the mesenchymal stromal cell (MSC), a multipotent progenitor cell, is attributed to small (50 to 200 nm) extracellular vesicles (EVs). The presence of a lipid membrane differentiates exosomes and EVs from other macromolecules. Analysis of this lipid ...
Read More »Shedding light on the cell biology of extracellular vesicles
Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising exosomes and microvesicles, which originate from the endosomal system or which are shed from the plasma membrane, respectively. They are present in biological fluids and are involved in multiple ...
Read More »Current knowledge on exosome biogenesis and release
Exosomes are nanosized membrane vesicles released by fusion of an organelle of the endocytic pathway, the multivesicular body, with the plasma membrane. This process was discovered more than 30 years ago, and during these years, exosomes have gone from being ...
Read More »Circulating microRNAs and long non-coding RNAs in gastric cancer diagnosis
Gastric cancer (GC) is the fourth most common cancer and the third leading cause of cancer mortality worldwide. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are the most popular non-coding RNAs in cancer research. To date, the roles of miRNAs ...
Read More »Biogenesis and secretion of exosomes
Although observed for several decades, the release of membrane-enclosed vesicles by cells into their surrounding environment has been the subject of increasing interest in the past few years, which led to the creation, in 2012, of a scientific society dedicated ...
Read More »Analysis of ESCRT functions in exosome biogenesis, composition and secretion
Exosomes are extracellular vesicles (EVs) secreted upon fusion of endosomal multivesicular bodies (MVBs) with the plasma membrane. The mechanisms involved in their biogenesis remain so far unclear although they constitute targets to modulate exosome formation and therefore are a promising ...
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